J Seguier1, P Guillaume-Jugnot2, M Ebbo2, L Daniel3, N Jourde-Chiche4, S Burtey4, E Bernit2, P Thomas5, J-R Harlé2, N Schleinitz2. 1. Service de médecine interne, Aix Marseille université, AP-HM, 147, boulevard Baille, 13385 Marseille cedex 5, France. Electronic address: julie.seguier@ap-hm.fr. 2. Service de médecine interne, Aix Marseille université, AP-HM, 147, boulevard Baille, 13385 Marseille cedex 5, France. 3. Service d'anatomopathologie, Aix Marseille université, AP-HM, 13385 Marseille cedex 5, France. 4. Service de néphrologie et transplantation rénale, Aix Marseille université, AP-HM, 13385 Marseille cedex 5, France. 5. Service de chirurgie thoracique, Aix Marseille université, AP-HM, 13385 Marseille cedex 5, France.
Abstract
INTRODUCTION: Malignant thymoma or thymic hyperplasia is associated with various autoimmune diseases. Renal disease has rarely been reported in this condition. We report a new case with improvement of renal disease after thymectomy. CASE REPORT: A 77-year-old-women with nephritic syndrome was found to have associated thymic mass. Renal pathology showed membranous nephropathy. The thymic mass pathology showed a B2 type thymoma. After thymectomy the nephrotic syndrome improved. CONCLUSION: Glomerulopathy can be secondary to an acquired thymic disease. Membranous nephropathy but also other glomerular diseases can be observed often presenting with nephritic syndrome. Despite the rarity of this association this clinical observation underlines that a thymoma should be searched in the presence of a glomerulopathy. The glomerulopathy can be improved by the treatment of the thymoma.
INTRODUCTION:Malignant thymoma or thymic hyperplasia is associated with various autoimmune diseases. Renal disease has rarely been reported in this condition. We report a new case with improvement of renal disease after thymectomy. CASE REPORT: A 77-year-old-women with nephritic syndrome was found to have associated thymic mass. Renal pathology showed membranous nephropathy. The thymic mass pathology showed a B2 type thymoma. After thymectomy the nephrotic syndrome improved. CONCLUSION:Glomerulopathy can be secondary to an acquired thymic disease. Membranous nephropathy but also other glomerular diseases can be observed often presenting with nephritic syndrome. Despite the rarity of this association this clinical observation underlines that a thymoma should be searched in the presence of a glomerulopathy. The glomerulopathy can be improved by the treatment of the thymoma.