Maddalena De Bernardo1, Luigi Capasso2, Antonia Tortori2, Michele Lanza3, Luisa Caliendo1, Nicola Rosa4. 1. Department of Medicine and Surgery, University of Salerno, Salerno, Italy. 2. U.O.C. Prelievo e Trapianto Cornee, Pellegrini Hospital, Naples, Italy. 3. 2nd University of Naples, Naples, Italy. 4. Department of Medicine and Surgery, University of Salerno, Salerno, Italy. Electronic address: nrosa@unisa.it.
Abstract
PURPOSE: To evaluate keratoconus biomechanical changes after transepithelial corneal collagen cross linking (TE CXL) using riboflavin and ultraviolet A (UVA). SETTING: Second University of Naples, Naples, Italy. DESIGN: Prospective non comparative case series study. METHODS: Patients with progressive keratoconus were examined, before and during a 6 months follow up after TE CXL, with a Pentacam, an Ocular Response Analyzer and an IOLMaster. Best corrected visual acuity (BCVA), refraction, corneal thinnest point (CTP), keratometry readings at the keratoconus apex (Kmax), axial eye length (AL), corneal volume (CV) anterior chamber volume (ACV), anterior chamber depth (ACD), corneal hysteresis (CH) and corneal resistance factor (CRF) were evaluated. RESULTS: Thirty-six eyes of 36 patients with progressive keratoconus were analyzed. Six months after treatment there was a significant improvement in BCVA (p<0.01), no significant changes in refraction (p=0.57), CTP (p=0.07), Kmax (p=0.88), AL (p=0.07), CV (p=0.38), ACV (p=0.07), ACD (p=0.7), CH (p=0.1) and CRF (p=0.3). CONCLUSIONS: According to our results TE CXL stabilizes most of the patients with progressive keratoconus, without affecting in negative way the corneal elasticity.
PURPOSE: To evaluate keratoconus biomechanical changes after transepithelial corneal collagen cross linking (TE CXL) using riboflavin and ultraviolet A (UVA). SETTING: Second University of Naples, Naples, Italy. DESIGN: Prospective non comparative case series study. METHODS:Patients with progressive keratoconus were examined, before and during a 6 months follow up after TE CXL, with a Pentacam, an Ocular Response Analyzer and an IOLMaster. Best corrected visual acuity (BCVA), refraction, corneal thinnest point (CTP), keratometry readings at the keratoconus apex (Kmax), axial eye length (AL), corneal volume (CV) anterior chamber volume (ACV), anterior chamber depth (ACD), corneal hysteresis (CH) and corneal resistance factor (CRF) were evaluated. RESULTS: Thirty-six eyes of 36 patients with progressive keratoconus were analyzed. Six months after treatment there was a significant improvement in BCVA (p<0.01), no significant changes in refraction (p=0.57), CTP (p=0.07), Kmax (p=0.88), AL (p=0.07), CV (p=0.38), ACV (p=0.07), ACD (p=0.7), CH (p=0.1) and CRF (p=0.3). CONCLUSIONS: According to our results TE CXL stabilizes most of the patients with progressive keratoconus, without affecting in negative way the corneal elasticity.
Authors: Ramón Alifa; David Piñero; José Velázquez; Jorge L Alió Del Barrio; Francisco Cavas; Jorge L Alió Journal: Diagnostics (Basel) Date: 2020-06-11