| Literature DB >> 25172662 |
Pengfei Zhu1, Jun Lv2, Ziwei Yang1, Limei Guo3, Ling Zhang4, Meng Li1, Wenling Han5, Xiangmei Chen6, Hui Zhuang1, Fengmin Lu7.
Abstract
Protocadherin 9 (PCDH9) was found frequently lost in hepatocellular carcinoma (HCC). Here we investigated the role of PCDH9 in the development of HCC. We confirmed that PCDH9 was down-regulated in HCC tissues and cell lines compared with the adjacent non-tumor tissues. PCDH9 downregulation was significantly associated with malignant portal vein invasion of HCC patients. Gain- and loss-of-function studies revealed that downregulation of PCDH9 facilitated tumor cell migration and epithelial-mesenchymal transition (EMT). We identified PCDH9 as a novel regulator of EMT by increasing the activity of GSK-3β and inhibiting Snail1, indicating its potential therapeutic value for reducing metastasis of HCC.Entities:
Keywords: EMT; GSK-3β; Hepatocellular carcinoma; Protocadherin 9; Tumor suppressor gene
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Year: 2014 PMID： 25172662 DOI： 10.1016/j.bbrc.2014.08.101
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575