Literature DB >> 25172548

Small molecule Mcl-1 inhibitors for the treatment of cancer.

Johannes Belmar1, Stephen W Fesik2.   

Abstract

The Bcl-2 family of proteins serves as primary regulators of apoptosis. Myeloid cell leukemia 1 (Mcl-1), a pro-survival member of the Bcl-2 family of proteins, is overexpressed and the Mcl-1 gene is amplified in many tumor types. Moreover, the overexpression of Mcl-1 is the cause of resistance to several chemotherapeutic agents. Thus, Mcl-1 is a promising cancer target. This review highlights the current progress on the discovery of small molecule Mcl-1 inhibitors.
Copyright © 2014 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  BH3-mimetic; Inhibitors; Mcl-1; Myeloid cell leukemia-1; Small molecule

Mesh：

Substances：

Year:  2014        PMID： 25172548      PMCID： PMC4340597          DOI： 10.1016/j.pharmthera.2014.08.003

Source DB:  PubMed          Journal:  Pharmacol Ther        ISSN： 0163-7258            Impact factor:   12.310


  91 in total

1.  Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia.

Authors:  Marina Konopleva; Rooha Contractor; Twee Tsao; Ismael Samudio; Peter P Ruvolo; Shinichi Kitada; Xingming Deng; Dayong Zhai; Yue-Xi Shi; Thomas Sneed; Monique Verhaegen; Maria Soengas; Vivian R Ruvolo; Teresa McQueen; Wendy D Schober; Julie C Watt; Tilahun Jiffar; Xiaoyang Ling; Frank C Marini; David Harris; Martin Dietrich; Zeev Estrov; James McCubrey; W Stratford May; John C Reed; Michael Andreeff
Journal:  Cancer Cell       Date:  2006-11       Impact factor: 31.743

2.  Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis.

Authors:  Mai Nguyen; Richard C Marcellus; Anne Roulston; Mark Watson; Lucile Serfass; S R Murthy Madiraju; Daniel Goulet; Jean Viallet; Laurent Bélec; Xavier Billot; Stephane Acoca; Enrico Purisima; Adrian Wiegmans; Leonie Cluse; Ricky W Johnstone; Pierre Beauparlant; Gordon C Shore
Journal:  Proc Natl Acad Sci U S A       Date:  2007-11-26       Impact factor: 11.205

3.  The N terminus of the anti-apoptotic BCL-2 homologue MCL-1 regulates its localization and function.

Authors:  Marc Germain; Vincent Duronio
Journal:  J Biol Chem       Date:  2007-09-06       Impact factor: 5.157

4.  Influence of Bcl-2 family members on the cellular response of small-cell lung cancer cell lines to ABT-737.

Authors:  Stephen K Tahir; Xiufen Yang; Mark G Anderson; Susan E Morgan-Lappe; Aparna V Sarthy; Jun Chen; Robert B Warner; Shi-Chung Ng; Stephen W Fesik; Steve W Elmore; Saul H Rosenberg; Christin Tse
Journal:  Cancer Res       Date:  2007-02-01       Impact factor: 12.701

5.  Alterations in the Noxa/Mcl-1 axis determine sensitivity of small cell lung cancer to the BH3 mimetic ABT-737.

Authors:  Paula Hauck; Bo H Chao; Julie Litz; Geoffrey W Krystal
Journal:  Mol Cancer Ther       Date:  2009-04       Impact factor: 6.261

6.  ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets.

Authors:  Andrew J Souers; Joel D Leverson; Erwin R Boghaert; Scott L Ackler; Nathaniel D Catron; Jun Chen; Brian D Dayton; Hong Ding; Sari H Enschede; Wayne J Fairbrother; David C S Huang; Sarah G Hymowitz; Sha Jin; Seong Lin Khaw; Peter J Kovar; Lloyd T Lam; Jackie Lee; Heather L Maecker; Kennan C Marsh; Kylie D Mason; Michael J Mitten; Paul M Nimmer; Anatol Oleksijew; Chang H Park; Cheol-Min Park; Darren C Phillips; Andrew W Roberts; Deepak Sampath; John F Seymour; Morey L Smith; Gerard M Sullivan; Stephen K Tahir; Chris Tse; Michael D Wendt; Yu Xiao; John C Xue; Haichao Zhang; Rod A Humerickhouse; Saul H Rosenberg; Steven W Elmore
Journal:  Nat Med       Date:  2013-01-06       Impact factor: 53.440

7.  Novel soluble myeloid cell leukemia sequence 1 (Mcl-1) inhibitor (E,E)-2-(benzylaminocarbonyl)-3-styrylacrylonitrile (4g) developed using a fragment-based approach.

Authors:  Zhichao Zhang; Ting Song; Xiangqian Li; Zhiyong Wu; Yingang Feng; Feibo Xie; Chengwu Liu; Jianquan Qin; Hongbo Chen
Journal:  Eur J Med Chem       Date:  2012-11-07       Impact factor: 6.514

8.  Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1.

Authors:  Joseph T Opferman; Anthony Letai; Caroline Beard; Mia D Sorcinelli; Christy C Ong; Stanley J Korsmeyer
Journal:  Nature       Date:  2003-12-11       Impact factor: 49.962

9.  Myeloid cell leukemia-1 inversely correlates with glycogen synthase kinase-3beta activity and associates with poor prognosis in human breast cancer.

Authors:  Qingqing Ding; Xianghuo He; Weiya Xia; Jung-Mao Hsu; Chun-Te Chen; Long-Yuan Li; Dung-Fang Lee; Jer-Yen Yang; Xiaoming Xie; Jaw-Ching Liu; Mien-Chie Hung
Journal:  Cancer Res       Date:  2007-05-10       Impact factor: 12.701

10.  Mechanism of synergy of N-(4-hydroxyphenyl)retinamide and ABT-737 in acute lymphoblastic leukemia cell lines: Mcl-1 inactivation.

Authors:  Min H Kang; Zesheng Wan; Yun Hee Kang; Richard Sposto; C Patrick Reynolds
Journal:  J Natl Cancer Inst       Date:  2008-04-08       Impact factor: 13.506
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  65 in total

1.  Inhibitors of the Antiapoptotic Myeloid Cell Leukemia-1 (Mcl-1) May Provide Effective Treatment for Cancer.

Authors:  Ahmed F Abdel-Magid
Journal:  ACS Med Chem Lett       Date:  2015-11-30       Impact factor: 4.345

Review 2.  Emerging understanding of Bcl-2 biology: Implications for neoplastic progression and treatment.

Authors:  Cristina Correia; Sun-Hee Lee; X Wei Meng; Nicole D Vincelette; Katherine L B Knorr; Husheng Ding; Grzegorz S Nowakowski; Haiming Dai; Scott H Kaufmann
Journal:  Biochim Biophys Acta       Date:  2015-03-27

3.  Inhibition of Mcl-1 through covalent modification of a noncatalytic lysine side chain.

Authors:  Gizem Akçay; Matthew A Belmonte; Brian Aquila; Claudio Chuaqui; Alexander W Hird; Michelle L Lamb; Philip B Rawlins; Nancy Su; Sharon Tentarelli; Neil P Grimster; Qibin Su
Journal:  Nat Chem Biol       Date:  2016-09-05       Impact factor: 15.040

4.  Nedaplatin enhanced apoptotic effects of ABT-737 in human cancer cells via Mcl-1 inhibition.

Authors:  Chong Zhang; Yang-Ling Li; Xu Weng; Li-Yan Li; Ming-Xian Zhou; Da-Yong Zhang; Neng-Ming Lin
Journal:  Oncol Lett       Date:  2016-09-20       Impact factor: 2.967

5.  Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy.

Authors:  Rongqing Pan; Vivian Ruvolo; Hong Mu; Joel D Leverson; Gwen Nichols; John C Reed; Marina Konopleva; Michael Andreeff
Journal:  Cancer Cell       Date:  2017-12-11       Impact factor: 31.743

6.  Iterative optimization yields Mcl-1-targeting stapled peptides with selective cytotoxicity to Mcl-1-dependent cancer cells.

Authors:  Raheleh Rezaei Araghi; Gregory H Bird; Jeremy A Ryan; Justin M Jenson; Marina Godes; Jonathan R Pritz; Robert A Grant; Anthony Letai; Loren D Walensky; Amy E Keating
Journal:  Proc Natl Acad Sci U S A       Date:  2018-01-16       Impact factor: 11.205

Review 7.  The BCL2 Family: Key Mediators of the Apoptotic Response to Targeted Anticancer Therapeutics.

Authors:  Aaron N Hata; Jeffrey A Engelman; Anthony C Faber
Journal:  Cancer Discov       Date:  2015-04-20       Impact factor: 39.397

8.  DARC: Mapping Surface Topography by Ray-Casting for Effective Virtual Screening at Protein Interaction Sites.

Authors:  Ragul Gowthaman; Sven A Miller; Steven Rogers; Jittasak Khowsathit; Lan Lan; Nan Bai; David K Johnson; Chunjing Liu; Liang Xu; Asokan Anbanandam; Jeffrey Aubé; Anuradha Roy; John Karanicolas
Journal:  J Med Chem       Date:  2015-07-10       Impact factor: 7.446

9.  Impact of BMI1 expression on the apoptotic effect of paclitaxel in colorectal cancer.

Authors:  Hsiang-Lin Tsai; Shin-Yu Pang; Hui-Ching Wang; Chi-Wen Luo; Qiao-Lin Li; Tzu-Yi Chen; Shao-Yu Fang; Jaw-Yuan Wang; Mei-Ren Pan
Journal:  Am J Cancer Res       Date:  2019-11-01       Impact factor: 6.166

10.  Discovery and Characterization of 2,5-Substituted Benzoic Acid Dual Inhibitors of the Anti-apoptotic Mcl-1 and Bfl-1 Proteins.

Authors:  Karson J Kump; Lei Miao; Ahmed S A Mady; Nurul H Ansari; Uttar K Shrestha; Yuting Yang; Mohan Pal; Chenzhong Liao; Andrej Perdih; Fardokht A Abulwerdi; Krishnapriya Chinnaswamy; Jennifer L Meagher; Jacob M Carlson; May Khanna; Jeanne A Stuckey; Zaneta Nikolovska-Coleska
Journal:  J Med Chem       Date:  2020-02-14       Impact factor: 7.446
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