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Literature DB >> 25172171

A review on lecithin:cholesterol acyltransferase deficiency.

Ramesh Saeedi¹, Min Li², Jiri Frohlich³.

Abstract

Lecithin cholesterol acyl transferase (LCAT) is a plasma enzyme which esterifies cholesterol, and plays a key role in the metabolism of high-density lipoprotein cholesterol (HDL-C). Genetic disorders of LCAT are associated with lipoprotein abnormalities including low levels of HDL-C and presence of lipoprotein X, and clinical features mainly corneal opacities, changes in erythrocyte morphology and renal failure. Recombinant LCAT is being developed for the treatment of patients with LCAT deficiency.

Entities: Chemical Disease Gene Species

Keywords: Cholesterol; FED; FLD; HDL; LCAT deficiency

Mesh：

Substances：

Year: 2014 PMID： 25172171 DOI： 10.1016/j.clinbiochem.2014.08.014

Source DB: PubMed Journal: Clin Biochem ISSN： 0009-9120 Impact factor: 3.281

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Cited

18 in total

Review 1. HDL and atherosclerotic cardiovascular disease: genetic insights into complex biology.

Authors: Robert S Rosenson; H Bryan Brewer; Philip J Barter; Johan L M Björkegren; M John Chapman; Daniel Gaudet; Daniel Seung Kim; Eric Niesor; Kerry-Anne Rye; Frank M Sacks; Jean-Claude Tardif; Robert A Hegele
Journal: Nat Rev Cardiol Date: 2017-08-10 Impact factor: 32.419

2. A case of acquired lecithin:cholesterol acyltransferase deficiency with sarcoidosis that remitted spontaneously.

Authors: Tanino Akiko; Takafumi Okura; Tomoaki Nagao; Masayoshi Kukida; Daijiro Enomoto; Ken-Ichi Miyoshi; Jitsuo Higaki; Masayuki Kuroda; Hideaki Bujo
Journal: CEN Case Rep Date: 2016-06-07

3. A Lipolytic Lecithin:Cholesterol Acyltransferase Secreted by Toxoplasma Facilitates Parasite Replication and Egress.

Authors: Viviana Pszenny; Karen Ehrenman; Julia D Romano; Andrea Kennard; Aric Schultz; David S Roos; Michael E Grigg; Vern B Carruthers; Isabelle Coppens
Journal: J Biol Chem Date: 2015-12-22 Impact factor: 5.157

Review 4. [Inborn errors of high-density lipoprotein metabolism].

Authors: Arnold von Eckardstein
Journal: Internist (Berl) Date: 2019-12 Impact factor: 0.743

5. A rare case of renal involvement in Lecithin-Cholesterol Acyltransferase (LCAT) deficiency: lessons for the clinical nephrologist.

Authors: Ashutosh Rath; Zafirah Zahir; Manoj Jain; Manas Ranjan Patel
Journal: J Nephrol Date: 2022-09-26 Impact factor: 4.393

6. LCAT deficiency and pregnancy: Case report.

Authors: Raul Leal-Gonzalez; Álvaro Ramos-Reyes; Mariana Moncada-Madrazo; Irasema Apodaca-Ramos; Kimberly L Morales-Palomino; Alejandro Valdés-Cepeda; César A Marrufo-García; Hugo A Rangel-Nava
Journal: Obstet Med Date: 2020-09-09

7. A Systematic Investigation of Structure/Function Requirements for the Apolipoprotein A-I/Lecithin Cholesterol Acyltransferase Interaction Loop of High-density Lipoprotein.

Authors: Xiaodong Gu; Zhiping Wu; Ying Huang; Matthew A Wagner; Camelia Baleanu-Gogonea; Ryan A Mehl; Jennifer A Buffa; Anthony J DiDonato; Leah B Hazen; Paul L Fox; Valentin Gogonea; John S Parks; Joseph A DiDonato; Stanley L Hazen
Journal: J Biol Chem Date: 2016-01-21 Impact factor: 5.157