Gert Klug1, Hans-Josef Feistritzer1, Sebastian J Reinstadler1, Agnes Mayr2, Christian Kremser2, Michael Schocke2, Wolfgang M Franz1, Bernhard Metzler3. 1. University Clinic of Internal Medicine III, Cardiology, Innsbruck Medical University, Anichstraße 35, A-6020 Innsbruck, Austria. 2. Department of Radiology I, Innsbruck Medical University, Anichstraße 35, A-6020 Innsbruck, Austria. 3. University Clinic of Internal Medicine III, Cardiology, Innsbruck Medical University, Anichstraße 35, A-6020 Innsbruck, Austria. Electronic address: Bernhard.Metzler@uki.at.
Abstract
INTRODUCTION: Cardiac magnetic resonance (CMR) is a unique method to determine regional and local aortic stiffness parameters. Although various methods have been validated, there are no data in patients after acute ST-segment elevation myocardial infarction (STEMI). In the present study we assessed the feasibility of different CMR derived measures of aortic stiffness in patients after first acute STEMI for the first time. METHODS: CMR derived aortic pulse wave velocity (PWV) determined by the regional transit-time (PWVTT) and local flow-area (PWVQA) method as well as local distensibility coefficients (DCs) was analyzed in 22 healthy young volunteers and 28 patients with recent acute STEMI. RESULTS: PWVTT and DC of the ascending aorta differed significantly between healthy subjects and STEMI patients (all p<0.001). PWVQA at thoracic levels of aorta was not different between groups (p>0.520) and did not correlate with age (p>0.149) and PWVTT (p>0.310). Intra- and interobserver variability was high for PWVTT (r=0.970, p<0.001 and r=0.920, p<0.001), acceptable for DC (all r>0. 809, p<0.001 and all r>0.510, p<0.001) but low for thoracic PWVQA (all r<0.330 and all r<0.372). CONCLUSION: PWVTT and local DC are robust methods for the assessment of aortic stiffness in patients after acute STEMI.
INTRODUCTION: Cardiac magnetic resonance (CMR) is a unique method to determine regional and local aortic stiffness parameters. Although various methods have been validated, there are no data in patients after acute ST-segment elevation myocardial infarction (STEMI). In the present study we assessed the feasibility of different CMR derived measures of aortic stiffness in patients after first acute STEMI for the first time. METHODS: CMR derived aortic pulse wave velocity (PWV) determined by the regional transit-time (PWVTT) and local flow-area (PWVQA) method as well as local distensibility coefficients (DCs) was analyzed in 22 healthy young volunteers and 28 patients with recent acute STEMI. RESULTS: PWVTT and DC of the ascending aorta differed significantly between healthy subjects and STEMI patients (all p<0.001). PWVQA at thoracic levels of aorta was not different between groups (p>0.520) and did not correlate with age (p>0.149) and PWVTT (p>0.310). Intra- and interobserver variability was high for PWVTT (r=0.970, p<0.001 and r=0.920, p<0.001), acceptable for DC (all r>0. 809, p<0.001 and all r>0.510, p<0.001) but low for thoracic PWVQA (all r<0.330 and all r<0.372). CONCLUSION: PWVTT and local DC are robust methods for the assessment of aortic stiffness in patients after acute STEMI.
Authors: Hans-Josef Feistritzer; Sebastian J Reinstadler; Gert Klug; Christian Kremser; Benjamin Seidner; Regina Esterhammer; Michael F Schocke; Wolfgang-Michael Franz; Bernhard Metzler Journal: PLoS One Date: 2015-01-22 Impact factor: 3.240
Authors: Martin Reindl; Christina Tiller; Magdalena Holzknecht; Ivan Lechner; Nicolas Hein; Mathias Pamminger; Benjamin Henninger; Agnes Mayr; Hans-Josef Feistritzer; Gert Klug; Axel Bauer; Bernhard Metzler; Sebastian J Reinstadler Journal: J Am Heart Assoc Date: 2020-01-31 Impact factor: 5.501
Authors: Hans-Josef Feistritzer; Gert Klug; Sebastian J Reinstadler; Martin Reindl; Lea Niess; Timo Nalbach; Christian Kremser; Agnes Mayr; Bernhard Metzler Journal: J Am Heart Assoc Date: 2017-09-08 Impact factor: 5.501
Authors: Ivan Lechner; Martin Reindl; Christina Tiller; Magdalena Holzknecht; Sarah Niederreiter; Agnes Mayr; Gert Klug; Christoph Brenner; Axel Bauer; Bernhard Metzler; Sebastian Johannes Reinstadler Journal: Int J Cardiovasc Imaging Date: 2021-09-02 Impact factor: 2.357