Literature DB >> 25169020

In vivo protection by broadly neutralizing HIV antibodies.

Marit J van Gils1, Rogier W Sanders2.   

Abstract

Passive immunization studies, including a recent one by Pegu et al., have repeatedly shown that HIV-specific broadly neutralizing antibodies (bnAbs) protect rhesus macaques from HIV acquisition. In vitro neutralization potency and in vivo protection correlate very strongly, supporting the quest for an HIV vaccine that induces potent bnAbs.
Copyright © 2014 Elsevier Ltd. All rights reserved.

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Year:  2014        PMID： 25169020     DOI： 10.1016/j.tim.2014.08.006

Source DB:  PubMed          Journal:  Trends Microbiol        ISSN： 0966-842X            Impact factor:   17.079


  28 in total

1.  The Atomic Structure of the HIV-1 gp41 Transmembrane Domain and Its Connection to the Immunogenic Membrane-proximal External Region.

Authors:  Beatriz Apellániz; Edurne Rujas; Soraya Serrano; Koldo Morante; Kouhei Tsumoto; Jose M M Caaveiro; M Ángeles Jiménez; José L Nieva
Journal:  J Biol Chem       Date:  2015-03-18       Impact factor: 5.157

2.  Immunogenicity Evaluation of N-Glycans Recognized by HIV Broadly Neutralizing Antibodies.

Authors:  Sachin S Shivatare; Ting-Jen Rachel Cheng; Yang-Yu Cheng; Vidya S Shivatare; Tsung-I Tsai; Hong-Yang Chuang; Chung-Yi Wu; Chi-Huey Wong
Journal:  ACS Chem Biol       Date:  2021-08-15       Impact factor: 4.634

3.  Functional Optimization of Broadly Neutralizing HIV-1 Antibody 10E8 by Promotion of Membrane Interactions.

Authors:  Edurne Rujas; Daniel P Leaman; Sara Insausti; Lei Ortigosa-Pascual; Lei Zhang; Michael B Zwick; José L Nieva
Journal:  J Virol       Date:  2018-03-28       Impact factor: 5.103

4.  An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability.

Authors:  Marit J van Gils; Tom L G M van den Kerkhof; Gabriel Ozorowski; Christopher A Cottrell; Devin Sok; Matthias Pauthner; Jesper Pallesen; Natalia de Val; Anila Yasmeen; Steven W de Taeye; Anna Schorcht; Stephanie Gumbs; Inez Johanna; Karen Saye-Francisco; Chi-Hui Liang; Elise Landais; Xiaoyan Nie; Laura K Pritchard; Max Crispin; Garnett Kelsoe; Ian A Wilson; Hanneke Schuitemaker; Per Johan Klasse; John P Moore; Dennis R Burton; Andrew B Ward; Rogier W Sanders
Journal:  Nat Microbiol       Date:  2016-11-14       Impact factor: 17.745

5.  Binding of inferred germline precursors of broadly neutralizing HIV-1 antibodies to native-like envelope trimers.

Authors:  Kwinten Sliepen; Max Medina-Ramírez; Anila Yasmeen; John P Moore; Per Johan Klasse; Rogier W Sanders
Journal:  Virology       Date:  2015-10-01       Impact factor: 3.616

6.  Engineering and Characterization of a Fluorescent Native-Like HIV-1 Envelope Glycoprotein Trimer.

Authors:  Kwinten Sliepen; Thijs van Montfort; Gabriel Ozorowski; Laura K Pritchard; Max Crispin; Andrew B Ward; Rogier W Sanders
Journal:  Biomolecules       Date:  2015-10-23

7.  Adjuvant-enhanced CD4 T Cell Responses are Critical to Durable Vaccine Immunity.

Authors:  Karen A O Martins; Christopher L Cooper; Sabrina M Stronsky; Sarah L W Norris; Steven A Kwilas; Jesse T Steffens; Jacqueline G Benko; Sean A van Tongeren; Sina Bavari
Journal:  EBioMedicine       Date:  2015-11-27       Impact factor: 8.143

8.  Holes in the Glycan Shield of the Native HIV Envelope Are a Target of Trimer-Elicited Neutralizing Antibodies.

Authors:  Laura E McCoy; Marit J van Gils; Gabriel Ozorowski; Terrence Messmer; Bryan Briney; James E Voss; Daniel W Kulp; Matthew S Macauley; Devin Sok; Matthias Pauthner; Sergey Menis; Christopher A Cottrell; Jonathan L Torres; Jessica Hsueh; William R Schief; Ian A Wilson; Andrew B Ward; Rogier W Sanders; Dennis R Burton
Journal:  Cell Rep       Date:  2016-08-18       Impact factor: 9.423

Review 9.  Recent progress in broadly neutralizing antibodies to HIV.

Authors:  Devin Sok; Dennis R Burton
Journal:  Nat Immunol       Date:  2018-10-17       Impact factor: 31.250

10.  Presenting native-like HIV-1 envelope trimers on ferritin nanoparticles improves their immunogenicity.

Authors:  Kwinten Sliepen; Gabriel Ozorowski; Judith A Burger; Thijs van Montfort; Melissa Stunnenberg; Celia LaBranche; David C Montefiori; John P Moore; Andrew B Ward; Rogier W Sanders
Journal:  Retrovirology       Date:  2015-09-26       Impact factor: 4.602
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