Literature DB >> 25168832

APOL1 kidney risk alleles: population genetics and disease associations.

Sophie Limou1, George W Nelson1, Jeffrey B Kopp1, Cheryl A Winkler2.   

Abstract

APOL1 kidney disease is a unique case in the field of the genetics of common disease: 2 variants (termed G1 and G2) with high population frequency have been repeatedly associated with nondiabetic CKDs, with very strong effect size (odds ratios 3-29) in populations of sub-Saharan African descent. This review provides an update on the spectrum of APOL1 kidney disease and on the worldwide distribution of these kidney risk variants. We also summarize the proper way to run a recessive analysis on joint and independent effects of APOL1 G1 and G2 kidney risk variants.
Copyright © 2014 National Kidney Foundation, Inc. All rights reserved.

Entities:  

Keywords:  APOL1 demographics; African admixture; Apolipoprotein L1; Chronic kidney disease; Glomerular disease

Mesh：

Substances：

Year:  2014        PMID： 25168832      PMCID： PMC4157456          DOI： 10.1053/j.ackd.2014.06.005

Source DB:  PubMed          Journal:  Adv Chronic Kidney Dis        ISSN： 1548-5595            Impact factor:   3.620


  42 in total

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  81 in total

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2.  APOL1 Risk Variants Are Strongly Associated with HIV-Associated Nephropathy in Black South Africans.

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5.  Association of APOL1 With Heart Failure With Preserved Ejection Fraction in Postmenopausal African American Women.

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Review 10.  The Genetics of Nephrotic Syndrome.

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