Yasuaki Hayashino1, Tsuyoshi Mashitani2, Satoru Tsujii3, Hitoshi Ishii3. 1. Department of Endocrinology, Tenri Hospital, Tenri, Nara, Japan hayasino-y@umin.net. 2. Department of Diabetology, Nara Medical University, Kashihara, Nara, Japan. 3. Department of Endocrinology, Tenri Hospital, Tenri, Nara, Japan.
Abstract
OBJECTIVE: To assess the prospective association between baseline serum hs-CRP concentration and the subsequent risk of development or progression of diabetic nephropathy. RESEARCH DESIGN AND METHODS: Longitudinal data were obtained from 2,518 patients with type 2 diabetes registered in a Japanese diabetes registry. To assess the independent correlations between serum baseline hs-CRP and either the development or progression of diabetic nephropathy 1 year later, the Cox proportional hazards model was used and adjusted for potential confounders. RESULTS: The mean patient age, BMI, and HbA1c level were 66.1 years, 24.6 kg/m2, and 7.5% (57.6 mmol/mol), respectively. Baseline serum hs-CRP levels were significantly associated with the urinary albumin-to-creatinine ratio at baseline (P < 0.001). Multivariable adjusted hazard ratio for the development from normoalbuminuria to microalbuminuria was 1.31 (95% CI 0.80-2.17; P = 0.286), 1.55 (1.16-2.08; P = 0.003), and 1.57 (1.22-2.03; P = 0.001), respectively, for the second, third, and fourth quartiles of serum hs-CRP levels, showing a statistically significant linear trend across categories (P < 0.001). We did not observe a significant association between hs-CRP levels and the subsequent risk of diabetic nephropathy progression (P for trend = 0.575). CONCLUSIONS: Serum hs-CRP levels, independent of possible confounders, were associated with a subsequent risk of developing, not progressing, diabetic nephropathy in type 2 diabetic patients. Serum hs-CRP may be useful for predicting the future risk of developing diabetic nephropathy.
OBJECTIVE: To assess the prospective association between baseline serum hs-CRP concentration and the subsequent risk of development or progression of diabetic nephropathy. RESEARCH DESIGN AND METHODS: Longitudinal data were obtained from 2,518 patients with type 2 diabetes registered in a Japanese diabetes registry. To assess the independent correlations between serum baseline hs-CRP and either the development or progression of diabetic nephropathy 1 year later, the Cox proportional hazards model was used and adjusted for potential confounders. RESULTS: The mean patient age, BMI, and HbA1c level were 66.1 years, 24.6 kg/m2, and 7.5% (57.6 mmol/mol), respectively. Baseline serum hs-CRP levels were significantly associated with the urinary albumin-to-creatinine ratio at baseline (P < 0.001). Multivariable adjusted hazard ratio for the development from normoalbuminuria to microalbuminuria was 1.31 (95% CI 0.80-2.17; P = 0.286), 1.55 (1.16-2.08; P = 0.003), and 1.57 (1.22-2.03; P = 0.001), respectively, for the second, third, and fourth quartiles of serum hs-CRP levels, showing a statistically significant linear trend across categories (P < 0.001). We did not observe a significant association between hs-CRP levels and the subsequent risk of diabetic nephropathy progression (P for trend = 0.575). CONCLUSIONS: Serum hs-CRP levels, independent of possible confounders, were associated with a subsequent risk of developing, not progressing, diabetic nephropathy in type 2 diabeticpatients. Serum hs-CRP may be useful for predicting the future risk of developing diabetic nephropathy.
Authors: Satyesh K Sinha; Susanne B Nicholas; Jung Hye Sung; Adolfo Correa; Tripathi B Rajavashisth; Keith C Norris; Jae Eun Lee Journal: Diabetes Care Date: 2019-09-11 Impact factor: 17.152
Authors: Anna C Rivara; Margaret Corley; Courtney C Choy; Rachel L Duckham; Alysa Pomer; Muagututia Sefuiva Reupena; Satupaitea Viali; Take Naseri; Erin E Kershaw; Scott E Crouter; Stephen T McGarvey; Richard G Bribiescas; Claudia Valeggia; Nicola L Hawley Journal: Am J Hum Biol Date: 2021-07-14 Impact factor: 1.937