Volume isotropic simultaneous interleaved black- and bright-blood imaging: a novel sequence for contrast-enhanced screening of brain metastasis.

We introduced and optimized a novel sequence of fast (about 4 min), volumetric, high resolution, simultaneous bright- and black-blood imaging with sufficient T1 contrast between enhanced metastasis and surrounding brain parenchyma for their differentiation. This proposed sequence can be used for 3-dimensional volumetric T1-weighted bright- and black-blood imaging in contrast-enhanced studies and may be promising for detecting small brain metastases by improving differentiation between blood vessels and small brain metastases.