Branka Bukvic1, Vladan Zivaljevic2, Sandra Sipetic3, Aleksandar Diklic2, Katarina Tausanovic2, Dragos Stojanovic4, Dejan Stevanovic4, Ivan Paunovic2. 1. Department for Doctoral Studies, Institute for Epidemiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia; Department of Gynecology and Obstetrics, General Hospital Uzice, Health Center Uzice, Uzice, Serbia. Electronic address: bukvicbranka@gmail.com. 2. Department of Surgery, Faculty of Medicine, University of Belgrade, Center for Endocrine Surgery, Clinical Center of Serbia, Belgrade, Serbia. 3. Department for Doctoral Studies, Institute for Epidemiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia. 4. Department of Surgery, Zemun Hospital, Belgrade, Serbia.
Abstract
BACKGROUND: The most common causes of hyperthyroidism are Graves disease (GD) and toxic nodular goiter (TNG). GD and TNG might influence patients' quality of life (QoL). The aim of our study was to analyze and compare the QoL of patients with GD with that of TNG patients and to evaluate the influence of surgical treatment on their QoL. MATERIALS AND METHODS: A prospective case-control study was conducted at the Center for Endocrine surgery in Belgrade, Serbia. The ThyPRO questionnaire was used in the QoL assessment of the GD and TNG patients (31 and 28, respectively) pre- and post-operatively. RESULTS: All patients were receiving antithyroid drugs, and none of the patients were overtly hyperthyroid at the time of completing the preoperative questionnaire. The QoL of the GD patients was worse than that of the TNG patients, with significant differences in eye symptoms, anxiety, and sex life domains (P < 0.001, P = 0.005, and P = 0.004, respectively), preoperatively, and in eye symptoms, anxiety, emotional susceptibility, and overall QoL (P = 0.001, P = 0.027, P = 0.005 and P = 0.013, respectively), postoperatively. The improvement in QoL in the GD patients was significant after surgical treatment in all ThyPRO domains. In the TNG patients, the improvement was significant in all but one ThyPRO domain, sex life (P = 0.066). CONCLUSIONS: The QoL of GD patients is worse than those of TNG patients. Surgery may improve QoL in patients with GD and TNG even if they have achieved satisfying thyroid status with medication treatment, preoperatively.
BACKGROUND: The most common causes of hyperthyroidism are Graves disease (GD) and toxic nodular goiter (TNG). GD and TNG might influence patients' quality of life (QoL). The aim of our study was to analyze and compare the QoL of patients with GD with that of TNGpatients and to evaluate the influence of surgical treatment on their QoL. MATERIALS AND METHODS: A prospective case-control study was conducted at the Center for Endocrine surgery in Belgrade, Serbia. The ThyPRO questionnaire was used in the QoL assessment of the GD and TNGpatients (31 and 28, respectively) pre- and post-operatively. RESULTS: All patients were receiving antithyroid drugs, and none of the patients were overtly hyperthyroid at the time of completing the preoperative questionnaire. The QoL of the GDpatients was worse than that of the TNGpatients, with significant differences in eye symptoms, anxiety, and sex life domains (P < 0.001, P = 0.005, and P = 0.004, respectively), preoperatively, and in eye symptoms, anxiety, emotional susceptibility, and overall QoL (P = 0.001, P = 0.027, P = 0.005 and P = 0.013, respectively), postoperatively. The improvement in QoL in the GDpatients was significant after surgical treatment in all ThyPRO domains. In the TNGpatients, the improvement was significant in all but one ThyPRO domain, sex life (P = 0.066). CONCLUSIONS: The QoL of GDpatients is worse than those of TNGpatients. Surgery may improve QoL in patients with GD and TNG even if they have achieved satisfying thyroid status with medication treatment, preoperatively.
Authors: Natalia Chaves; M Juanita Rodriguez; Jordan M Broekhuis; Hao Wei Chen; Paul A Bain; Benjamin C James Journal: World J Surg Date: 2022-01-24 Impact factor: 3.352
Authors: David J Stott; Jacobijn Gussekloo; Patricia M Kearney; Nicolas Rodondi; Rudi G J Westendorp; Simon Mooijaart; Sharon Kean; Terence J Quinn; Naveed Sattar; Kirsty Hendry; Robert Du Puy; Wendy P J Den Elzen; Rosalinde K E Poortvliet; Jan W A Smit; J Wouter Jukema; Olaf M Dekkers; Manuel Blum; Tinh-Hai Collet; Vera McCarthy; Caroline Hurley; Stephen Byrne; John Browne; Torquil Watt; Douglas Bauer; Ian Ford Journal: BMC Endocr Disord Date: 2017-02-03 Impact factor: 2.763