Literature DB >> 25165081

Rapid sequencing of the Mycobacterium tuberculosis pncA gene for detection of pyrazinamide susceptibility.

Elizabeth M Streicher1, Kashmeel Maharaj2, Talita York1, Carel Van Heerden3, Marinus Barnard4, Andreas Diacon4, Carl M Mendel5, Marlein E Bosman6, Juli A Hepple1, Alexander S Pym2, Robin M Warren7, Paul D van Helden1.   

Abstract

We developed a pyrazinamidase gene DNA-sequencing method to rapidly identify pyrazinamide resistance-causing mutations in GenoLyse-treated, smear-positive sputum specimens. The sensitivity and specificity were 90.9 and 100%, respectively, compared to those of MGIT drug susceptibility testing, after the exclusion of synonymous mutations and nonsynonymous mutations previously associated with susceptibility to pyrazinamide.
Copyright © 2014, American Society for Microbiology. All Rights Reserved.

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Year:  2014        PMID： 25165081      PMCID： PMC4313251          DOI： 10.1128/JCM.02438-14

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  12 in total

1.  Correlation between pyrazinamide activity and pncA mutations in Mycobacterium tuberculosis isolates in Taiwan.

Authors:  Tsi-Shu Huang; Susan Shin-Jung Lee; Hui-Zin Tu; Wen-Kuei Huang; Yao-Shen Chen; Chung-Kai Huang; Shue-Ren Wann; Hsi-Hsun Lin; Yung-Ching Liu
Journal:  Antimicrob Agents Chemother       Date:  2003-11       Impact factor: 5.191

2.  Pyrazinamide inhibits trans-translation in Mycobacterium tuberculosis.

Authors:  Wanliang Shi; Xuelian Zhang; Xin Jiang; Haiming Yuan; Jong Seok Lee; Clifton E Barry; Honghai Wang; Wenhong Zhang; Ying Zhang
Journal:  Science       Date:  2011-08-11       Impact factor: 47.728

3.  Potential for erroneous results indicating resistance when using the Bactec MGIT 960 system for testing susceptibility of Mycobacterium tuberculosis to pyrazinamide.

Authors:  Pamela Chedore; Lina Bertucci; Joyce Wolfe; Meenu Sharma; Frances Jamieson
Journal:  J Clin Microbiol       Date:  2009-11-18       Impact factor: 5.948

4.  Role of rpsA gene sequencing in diagnosis of pyrazinamide resistance.

Authors:  Sami O Simons; Arnout Mulder; Jakko van Ingen; Martin J Boeree; Dick van Soolingen
Journal:  J Clin Microbiol       Date:  2013-01       Impact factor: 5.948

Review 5.  The curious characteristics of pyrazinamide: a review.

Authors:  Y Zhang; D Mitchison
Journal:  Int J Tuberc Lung Dis       Date:  2003-01       Impact factor: 2.373

6.  Mutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, cause resistance to the antituberculous drug pyrazinamide in tubercle bacillus.

Authors:  A Scorpio; Y Zhang
Journal:  Nat Med       Date:  1996-06       Impact factor: 53.440

7.  Mutation in pncA is a major mechanism of pyrazinamide resistance in Mycobacterium tuberculosis.

Authors:  K Hirano; M Takahashi; Y Kazumi; Y Fukasawa; C Abe
Journal:  Tuber Lung Dis       Date:  1997

8.  Characterization of mutations in multi- and extensive drug resistance among strains of Mycobacterium tuberculosis clinical isolates in Republic of Korea.

Authors:  Hum Nath Jnawali; Sung Chul Hwang; Young Kil Park; Hyejin Kim; Yeong Seon Lee; Gyung Tae Chung; Kang Hyeon Choe; Sungweon Ryoo
Journal:  Diagn Microbiol Infect Dis       Date:  2013-04-02       Impact factor: 2.803

9.  Frequency and implications of pyrazinamide resistance in managing previously treated tuberculosis patients.

Authors:  G E Louw; R M Warren; P R Donald; M B Murray; M Bosman; P D Van Helden; D B Young; T C Victor
Journal:  Int J Tuberc Lung Dis       Date:  2006-07       Impact factor: 2.373

10.  Tuberculosis drug resistance mutation database.

Authors:  Andreas Sandgren; Michael Strong; Preetika Muthukrishnan; Brian K Weiner; George M Church; Megan B Murray
Journal:  PLoS Med       Date:  2009-02-10       Impact factor: 11.069
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  11 in total

1.  Direct Detection of Pyrazinamide Resistance in Mycobacterium tuberculosis by Use of pncA PCR Sequencing.

Authors:  Kingsley King-Gee Tam; Kenneth Siu-Sing Leung; Gilman Kit-Hang Siu; Kwok-Chiu Chang; Samson Sai-Yin Wong; Pak-Leung Ho; Eunice Ka-Chun Leung; Wing-Cheong Yam
Journal:  J Clin Microbiol       Date:  2019-07-26       Impact factor: 5.948

Review 2.  Mutations Associated with Pyrazinamide Resistance in Mycobacterium tuberculosis: A Review and Update.

Authors:  Ananthi Rajendran; Kannan Palaniyandi
Journal:  Curr Microbiol       Date:  2022-10-08       Impact factor: 2.343

3.  A Novel Molecular Strategy for Surveillance of Multidrug Resistant Tuberculosis in High Burden Settings.

Authors:  Halima M Said; Nicole Kushner; Shaheed V Omar; Andries W Dreyer; Hendrik Koornhof; Linda Erasmus; Yasmin Gardee; Ivy Rukasha; Elena Shashkina; Natalie Beylis; Gilla Kaplan; Dorothy Fallows; Nazir A Ismail
Journal:  PLoS One       Date:  2016-01-11       Impact factor: 3.240

4.  Pyrazinamide resistance and mutations in pncA among isolates of Mycobacterium tuberculosis from Khyber Pakhtunkhwa, Pakistan.

Authors:  Muhammad Tahir Khan; Shaukat Iqbal Malik; Sajid Ali; Nayyer Masood; Tariq Nadeem; Anwar Sheed Khan; Muhammad Tanvir Afzal
Journal:  BMC Infect Dis       Date:  2019-02-06       Impact factor: 3.090

5.  Resistance To First-Line Antituberculosis Drugs And Prevalence Of pncA Mutations In Clinical Isolates Of Mycobacterium tuberculosis From Zunyi, Guizhou Province Of China.

Authors:  Zhimin Cao; Yuanbo Lan; Ling Chen; Min Xiang; Zhiyuan Peng; Jianyong Zhang; Hong Zhang
Journal:  Infect Drug Resist       Date:  2019-09-30       Impact factor: 4.003

6.  Comparative Performance of Genomic Methods for the Detection of Pyrazinamide Resistance and Heteroresistance in Mycobacterium tuberculosis.

Authors:  Annelies Van Rie; John Z Metcalfe; Michael G Whitfield; David M Engelthaler; Christopher Allender; Megan Folkerts; Tim H Heupink; Jason Limberis; Robin M Warren
Journal:  J Clin Microbiol       Date:  2021-11-10       Impact factor: 5.948

7.  Implications of Failure to Routinely Diagnose Resistance to Second-Line Drugs in Patients With Rifampicin-Resistant Tuberculosis on Xpert MTB/RIF: A Multisite Observational Study.

Authors:  Karen R Jacobson; Marinus Barnard; Mary B Kleinman; Elizabeth M Streicher; Elizabeth J Ragan; Laura F White; Ofer Shapira; Tania Dolby; John Simpson; Lesley Scott; Wendy Stevens; Paul D van Helden; Annelies Van Rie; Robin M Warren
Journal:  Clin Infect Dis       Date:  2017-06-01       Impact factor: 9.079

Review 8.  A Global Perspective on Pyrazinamide Resistance: Systematic Review and Meta-Analysis.

Authors:  Michael G Whitfield; Heidi M Soeters; Robin M Warren; Talita York; Samantha L Sampson; Elizabeth M Streicher; Paul D van Helden; Annelies van Rie
Journal:  PLoS One       Date:  2015-07-28       Impact factor: 3.240

9.  Genomic and functional analyses of Mycobacterium tuberculosis strains implicate ald in D-cycloserine resistance.

Authors:  Christopher A Desjardins; Keira A Cohen; Vanisha Munsamy; Thomas Abeel; Kashmeel Maharaj; Bruce J Walker; Terrance P Shea; Deepak V Almeida; Abigail L Manson; Alex Salazar; Nesri Padayatchi; Max R O'Donnell; Koleka P Mlisana; Jennifer Wortman; Bruce W Birren; Jacques Grosset; Ashlee M Earl; Alexander S Pym
Journal:  Nat Genet       Date:  2016-04-11       Impact factor: 38.330

10.  Rapid Pyrazinamide Drug Susceptibility Testing using a Closed-Tube PCR Assay of the Entire pncA gene.

Authors:  Lawrence J Wangh; Barry N Kreiswirth; Michael G Whitfield; Salvatore A E Marras; Rob M Warren; Annelies Van Rie; John Rice
Journal:  Sci Rep       Date:  2020-03-06       Impact factor: 4.379
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