OBJECTIVE: To carry out the histological and histomorphometric plus radiological analysis of biphasic ceramic. MATERIALS AND METHOD: In this study, porous HA/βTCP (4Bone(®) ) ceramic material was tested for the bone repairing capacity and osteoinductive potential in a New Zealand rabbit model. The ratio of the ceramic's components HA/βTCP was 60/40 (in wt%). RESULTS: The 4Bone(®) showed significantly more bone formation in the pores and in the periphery of the graft than the control group. Histomorphometric analysis revealed that the ceramic material (66.43% ± 0.29) produced higher values of bone-to-implant contact (BIC) percentages (higher quality, closer contact); moreover, defect closure was significative higher in relation with control group (64.15% ± 3.52). CONCLUSIONS: 4Bone(®) is a biocompatible, partially resorbable and osteoconductive grafting material. Biphasic graft material of HA/βTCP with a porosity of 95% without loading favors new bone formation.
OBJECTIVE: To carry out the histological and histomorphometric plus radiological analysis of biphasic ceramic. MATERIALS AND METHOD: In this study, porous HA/βTCP (4Bone(®) ) ceramic material was tested for the bone repairing capacity and osteoinductive potential in a New Zealand rabbit model. The ratio of the ceramic's components HA/βTCP was 60/40 (in wt%). RESULTS: The 4Bone(®) showed significantly more bone formation in the pores and in the periphery of the graft than the control group. Histomorphometric analysis revealed that the ceramic material (66.43% ± 0.29) produced higher values of bone-to-implant contact (BIC) percentages (higher quality, closer contact); moreover, defect closure was significative higher in relation with control group (64.15% ± 3.52). CONCLUSIONS: 4Bone(®) is a biocompatible, partially resorbable and osteoconductive grafting material. Biphasic graft material of HA/βTCP with a porosity of 95% without loading favors new bone formation.
Authors: María Piedad Ramírez Fernández; Sergio A Gehrke; Carlos Pérez Albacete Martinez; Jose L Calvo Guirado; Piedad N de Aza Journal: Materials (Basel) Date: 2017-05-17 Impact factor: 3.623
Authors: Sergio Alexandre Gehrke; Patricia Mazón; Leticia Pérez-Díaz; José Luis Calvo-Guirado; Pablo Velásquez; Juan Manuel Aragoneses; Manuel Fernández-Domínguez; Piedad N De Aza Journal: Materials (Basel) Date: 2019-02-01 Impact factor: 3.623