The miRNA network: micro-regulator of cell signaling in cancer.

The dysregulation of cell signaling plays a pivotal role in tumorigenesis and progression. miRNAs have been linked to almost all known aspects of physiological and pathological processes. It is well known that the miRNA network is linked at several and unexpected levels with cancer-related signaling pathways. Our understanding of the roles and regulation of the miRNA network has been extended to include classical cell signaling, termed miRNA network complements cell signaling in cancer. As a transcription factor, tumor suppressor p53 plays a central role in tumor prevention. Recent studies have demonstrated that miRNAs may regulate the expression of the p53 pathway or be regulated by the p53 pathway. These findings added a new and challenging layer of complexity to the p53 pathway and prompted us to contemplate the use of the compensatory mechanisms in therapeutics against cancer. In this review, we have therefore summarized the p53 tumor suppressive pathway as a typical paradigm to elucidate the advances of the compensatory mechanisms. We then go on to critically discuss how the compensatory mechanisms can be used to enable better cancer diagnosis and prognosis and to serve as potential therapeutic targets.