Literature DB >> 25163410

Endoplasmic reticulum heat shock protein gp96/grp94 is a pro-oncogenic chaperone, not a tumor suppressor.

Saleh Rachidi1, Shaoli Sun, Zihai Li.   

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Year:  2015        PMID： 25163410      PMCID： PMC4939405          DOI： 10.1002/hep.27400

Source DB:  PubMed          Journal:  Hepatology        ISSN： 0270-9139            Impact factor:   17.425


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  5 in total

1.  Liver-specific knockout of GRP94 in mice disrupts cell adhesion, activates liver progenitor cells, and accelerates liver tumorigenesis.

Authors:  Wan-Ting Chen; Chun-Chih Tseng; Kyle Pfaffenbach; Gary Kanel; Biquan Luo; Bangyan L Stiles; Amy S Lee
Journal:  Hepatology       Date:  2014-01-27       Impact factor: 17.425

2.  Heat shock protein gp96 is a master chaperone for toll-like receptors and is important in the innate function of macrophages.

Authors:  Yi Yang; Bei Liu; Jie Dai; Pramod K Srivastava; David J Zammit; Leo Lefrançois; Zihai Li
Journal:  Immunity       Date:  2007-02-01       Impact factor: 31.745

3.  Hepatomas with activating Ctnnb1 mutations in 'Ctnnb1-deficient' livers: a tricky aspect of a conditional knockout mouse model.

Authors:  Shigeki Sekine; Reiko Ogawa; Yae Kanai
Journal:  Carcinogenesis       Date:  2011-01-07       Impact factor: 4.944

4.  gp96, an endoplasmic reticulum master chaperone for integrins and Toll-like receptors, selectively regulates early T and B lymphopoiesis.

Authors:  Matthew Staron; Yi Yang; Bei Liu; Janet Li; Yuankai Shen; Juan Carlos Zúñiga-Pflücker; Hector L Aguila; Irving Goldschneider; Zihai Li
Journal:  Blood       Date:  2009-11-13       Impact factor: 22.113

5.  GRP78 as a regulator of liver steatosis and cancer progression mediated by loss of the tumor suppressor PTEN.

Authors:  W-T Chen; G Zhu; K Pfaffenbach; G Kanel; B Stiles; A S Lee
Journal:  Oncogene       Date:  2013-10-21       Impact factor: 9.867
  5 in total
  6 in total

1.  Endoplasmic Reticulum-resident Heat Shock Protein 90 (HSP90) Isoform Glucose-regulated Protein 94 (GRP94) Regulates Cell Polarity and Cancer Cell Migration by Affecting Intracellular Transport.

Authors:  Suman Ghosh; Heather E Shinogle; Nadezhda A Galeva; Rick T Dobrowsky; Brian S J Blagg
Journal:  J Biol Chem       Date:  2016-02-12       Impact factor: 5.157

2.  Transformation of the Non-Selective Aminocyclohexanol-Based Hsp90 Inhibitor into a Grp94-Seletive Scaffold.

Authors:  Sanket J Mishra; Suman Ghosh; Andrew R Stothert; Chad A Dickey; Brian S J Blagg
Journal:  ACS Chem Biol       Date:  2016-12-13       Impact factor: 5.100

Review 3.  Clients and Oncogenic Roles of Molecular Chaperone gp96/grp94.

Authors:  Ephraim A Ansa-Addo; Jessica Thaxton; Feng Hong; Bill X Wu; Yongliang Zhang; Caroline W Fugle; Alessandra Metelli; Brian Riesenberg; Katelyn Williams; Daniel T Gewirth; Gabriela Chiosis; Bei Liu; Zihai Li
Journal:  Curr Top Med Chem       Date:  2016       Impact factor: 3.295

4.  Characterization of HSP90 isoforms in transformed bovine leukocytes infected with Theileria annulata.

Authors:  Jane H Kinnaird; Meetali Singh; Victoria Gillan; William Weir; Ewen D D Calder; Isabel Hostettler; Utpal Tatu; Eileen Devaney; Brian R Shiels
Journal:  Cell Microbiol       Date:  2016-10-20       Impact factor: 3.715

5.  Grp94 in complexes with IgG is a soluble diagnostic marker of gastrointestinal tumors and displays immune-stimulating activity on peripheral blood immune cells.

Authors:  Elisa Tramentozzi; Erlis Ruli; Imerio Angriman; Romeo Bardini; Michela Campora; Vincenza Guzzardo; Rita Zamarchi; Elisabetta Rossi; Massimo Rugge; Paola Finotti
Journal:  Oncotarget       Date:  2016-11-08

6.  Overexpression of molecule GRP94 favors tumor progression in lung adenocarcinoma by interaction with regulatory T cells.

Authors:  Xiao-Feng Duan; Ya-Wei Xin
Journal:  Thorac Cancer       Date:  2020-01-22       Impact factor: 3.500
  6 in total

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