| Literature DB >> 2515975 |
N Perrot1, B Nalpas, C S Yang, P H Beaune.
Abstract
Cytochromes P450 (P450) are a family of isozymes which play an important role in xenobiotic metabolism. The concentration of three P450 isozymes, namely P450-IIE1(A1c),-IIIA(NF) and -IIC8-10(MP) has been measured in human liver biopsies of patients with different alcohol and drug intake status. All these three P450s were expressed in all subjects. Ethanol intake increased P450-IIE1(A1c) content with no effect on the content of the two other P450s. Drug intake (barbiturates) increased both P450-IIIA(NF) and -IIC8-10(MP) content without any effect on P450-IIE1(A1c). This paper brought, at protein level, further evidence of the importance of environmental conditions on P450 isozyme pattern, and therefore, on drug metabolizing capacity of human liver.Entities:
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Year: 1989 PMID： 2515975 DOI： 10.1111/j.1365-2362.1989.tb00273.x
Source DB: PubMed Journal: Eur J Clin Invest ISSN： 0014-2972 Impact factor: 4.686