Literature DB >> 25159109

MSN-mediated sequential vascular-to-cell nuclear-targeted drug delivery for efficient tumor regression.

Limin Pan1, Jianan Liu, Qianjun He, Jianlin Shi.   

Abstract

Mesoporous silica nanoparticles functionalized with peptides are developed for sequential drug delivery. The RGD peptide is used for vasculature/cell membrane targeting and the TAT peptide for nuclear targeting. Using this delivery strategy, a tumor in a murine xenograft model is successfully regressed.
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  mesoporous materials; nuclear targeting; silica nanoparticles; targeted drug delivery; tumor regression

Mesh：

Substances：

Year:  2014        PMID： 25159109     DOI： 10.1002/adma.201402752

Source DB:  PubMed          Journal:  Adv Mater        ISSN： 0935-9648            Impact factor:   30.849


  24 in total

1.  Autophagy upregulation promotes macrophages to escape mesoporous silica nanoparticle (MSN)-induced NF-κB-dependent inflammation.

Authors:  Chen Xi; Jie Zhou; Shuzhang Du; Shaojun Peng
Journal:  Inflamm Res       Date:  2016-02-09       Impact factor: 4.575

2.  Acidity/Reducibility Dual-Responsive Hollow Mesoporous Organosilica Nanoplatforms for Tumor-Specific Self-Assembly and Synergistic Therapy.

Authors:  Wei Tang; Wenpei Fan; Zhantong Wang; Weizhong Zhang; Shiyi Zhou; Yijing Liu; Zhen Yang; Emily Shao; Guofeng Zhang; Orit Jacobson; Lingling Shan; Rui Tian; Siyuan Cheng; Lisen Lin; Yulun Dai; Zheyu Shen; Gang Niu; Jin Xie; Xiaoyuan Chen
Journal:  ACS Nano       Date:  2018-11-15       Impact factor: 15.881

Review 3.  Engineering mesoporous silica nanoparticles for drug delivery: where are we after two decades?

Authors:  María Vallet-Regí; Ferdi Schüth; Daniel Lozano; Montserrat Colilla; Miguel Manzano
Journal:  Chem Soc Rev       Date:  2022-07-04       Impact factor: 60.615

Review 4.  Development of individualized anti-metastasis strategies by engineering nanomedicines.

Authors:  Qianjun He; Shengrong Guo; Zhiyong Qian; Xiaoyuan Chen
Journal:  Chem Soc Rev       Date:  2015-06-09       Impact factor: 54.564

5.  In situ protein-templated porous protein-hydroxylapatite nanocomposite microspheres for pH-dependent sustained anticancer drug release.

Authors:  Yajun Shuai; Shuxu Yang; Chenlin Li; Liangjun Zhu; Chuanbin Mao; Mingying Yang
Journal:  J Mater Chem B       Date:  2017-05-12       Impact factor: 6.331

Review 6.  Advances in mesoporous silica nanoparticles for targeted stimuli-responsive drug delivery: an update.

Authors:  Rafael R Castillo; Daniel Lozano; Blanca González; Miguel Manzano; Isabel Izquierdo-Barba; María Vallet-Regí
Journal:  Expert Opin Drug Deliv       Date:  2019-04-22       Impact factor: 6.648

7.  Recent advances in porous nanostructures for cancer theranostics.

Authors:  Jinping Wang; Beilu Zhang; Jingyu Sun; Wei Hu; Hongjun Wang
Journal:  Nano Today       Date:  2021-04-08       Impact factor: 18.962

8.  Single peptide ligand-functionalized uniform hollow mesoporous silica nanoparticles achieving dual-targeting drug delivery to tumor cells and angiogenic blood vessel cells.

Authors:  Yang Liu; Qing Chen; Ming Xu; Guannan Guan; Wen Hu; Ying Liang; Xiuli Zhao; Mingxi Qiao; Dawei Chen; Hao Liu
Journal:  Int J Nanomedicine       Date:  2015-03-06

9.  Two birds, one stone: dual targeting of the cancer cell surface and subcellular mitochondria by the galectin-3-binding peptide G3-C12.

Authors:  Wei Sun; Lian Li; Li-Jia Li; Qing-Qing Yang; Zhi-Rong Zhang; Yuan Huang
Journal:  Acta Pharmacol Sin       Date:  2017-01-09       Impact factor: 6.150

10.  Dual-functionalized liposomal delivery system for solid tumors based on RGD and a pH-responsive antimicrobial peptide.

Authors:  Qianyu Zhang; Libao Lu; Li Zhang; Kairong Shi; Xingli Cun; Yuting Yang; Yayuan Liu; Huile Gao; Qin He
Journal:  Sci Rep       Date:  2016-02-04       Impact factor: 4.379
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