Literature DB >> 25158576

Hydrogen-containing saline attenuates doxorubicin-induced heart failure in rats.

Shujing Wu, Liqun Zhu, Jing Yang, Zhixin Fan, Yanli Dong, Rui Luan, Jingjing Cai, Lu Fu.   

Abstract

Interactions between doxorubicin (DOX) and iron generate reactive oxygen species and contribute to DOX-induced heart failure. Hydrogen, as a selective antioxidant, is a promising potential therapeutic option for the treatment of a variety of diseases. Therefore, we investigated the preventive effects of hydrogen treatment on DOX-induced heart failure in rats. We found that cardiac function was significantly improved and that the plasma levels of oxidative-stress markers and myocardial autophagic activity were decreased in animals treated with hydrogen-containing saline. Therefore, we conclude that hydrogen-containing saline may have beneficial effects for doxorubicin-induced heart failure.

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Year:  2014        PMID： 25158576

Source DB:  PubMed          Journal:  Pharmazie        ISSN： 0031-7144            Impact factor:   1.267


  11 in total

1.  MiR-181c protects cardiomyocyte injury by preventing cell apoptosis through PI3K/Akt signaling pathway.

Authors:  Xiaoli Li; Jiuchang Zhong; Zhen Zeng; Hongjiang Wang; Jing Li; Xiaoyan Liu; Xinchun Yang
Journal:  Cardiovasc Diagn Ther       Date:  2020-08

Review 2.  A review of experimental studies of hydrogen as a new therapeutic agent in emergency and critical care medicine.

Authors:  Meihua Shen; Hongying Zhang; Congjun Yu; Fan Wang; Xuejun Sun
Journal:  Med Gas Res       Date:  2014-11-08

3.  Beneficial biological effects and the underlying mechanisms of molecular hydrogen - comprehensive review of 321 original articles.

Authors:  Masatoshi Ichihara; Sayaka Sobue; Mikako Ito; Masafumi Ito; Masaaki Hirayama; Kinji Ohno
Journal:  Med Gas Res       Date:  2015-10-19

Review 4.  Modulation of Hypercholesterolemia-Induced Oxidative/Nitrative Stress in the Heart.

Authors:  Csaba Csonka; Márta Sárközy; Márton Pipicz; László Dux; Tamás Csont
Journal:  Oxid Med Cell Longev       Date:  2015-12-14       Impact factor: 6.543

Review 5.  Autophagy and mitophagy in the context of doxorubicin-induced cardiotoxicity.

Authors:  Navid Koleini; Elissavet Kardami
Journal:  Oncotarget       Date:  2017-07-11

6.  Hydrogen-containing saline alleviates pressure overload-induced interstitial fibrosis and cardiac dysfunction in rats.

Authors:  Jing Yang; Shujing Wu; Liqun Zhu; Jingjing Cai; Lu Fu
Journal:  Mol Med Rep       Date:  2017-06-23       Impact factor: 2.952

7.  Protective effect of hydrogen-rich saline on pressure overload-induced cardiac hypertrophyin rats: possible role of JAK-STAT signaling.

Authors:  Zhixin Fan; Yufei Gao; Zhiwei Huang; Fenghua Xue; Shujing Wu; Jing Yang; Liqun Zhu; Lu Fu
Journal:  BMC Cardiovasc Disord       Date:  2018-02-13       Impact factor: 2.298

8.  Inhalation of Hydrogen Attenuates Progression of Chronic Heart Failure via Suppression of Oxidative Stress and P53 Related to Apoptosis Pathway in Rats.

Authors:  Jing Chi; Zizhuo Li; Xiaojian Hong; Tong Zhao; Yueyue Bie; Wen Zhang; Jiaxing Yang; Ziming Feng; Zhouqi Yu; Qiannan Xu; Luqi Zhao; Weifan Liu; Yunan Gao; Hongxiao Yang; Jiemei Yang; Jiaren Liu; Wei Yang
Journal:  Front Physiol       Date:  2018-07-31       Impact factor: 4.566

9.  Hydrogen-rich saline mitigates pressure overload-induced cardiac hypertrophy and atrial fibrillation in rats via the JAK-STAT signalling pathway.

Authors:  Chufeng Wang; Zezheng Pan
Journal:  J Int Med Res       Date:  2020-08       Impact factor: 1.671

10.  Effects of long-term hydrogen intervention on the physiological function of rats.

Authors:  Zhi-Ming Xun; Qing-Hui Zhao; Yan Zhang; Fang-di Ju; Jin He; Ting-Ting Yao; Xiao-Kang Zhang; Yang Yi; Sheng-Nan Ma; Peng-Xiang Zhao; Xiao-Yan Jin; Ying-Xian Li; Xiao-Yang Li; Xue-Mei Ma; Fei Xie
Journal:  Sci Rep       Date:  2020-10-28       Impact factor: 4.379
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