Literature DB >> 2515816

Treatment of arsenical refractory Rhodesian sleeping sickness in Kenya.

J D Bales1, S M Harrison, D L Mbwabi, P J Schecter.   

Abstract

Case histories of three Rhodesian sleeping sickness patients who relapsed after Mel-B therapy are presented. Repeated Mel-B therapy was clinically effective but not curative, and all three patients subsequently relapsed again and required further treatment.

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Year:  1989        PMID： 2515816     DOI： 10.1080/00034983.1989.11812414

Source DB:  PubMed          Journal:  Ann Trop Med Parasitol        ISSN： 0003-4983


  7 in total

1.  In vitro trypanocidal activities of new S-adenosylmethionine decarboxylase inhibitors.

Authors:  R Brun; Y Bühler; U Sandmeier; R Kaminsky; C J Bacchi; D Rattendi; S Lane; S L Croft; D Snowdon; V Yardley; G Caravatti; J Frei; J Stanek; H Mett
Journal:  Antimicrob Agents Chemother       Date:  1996-06       Impact factor: 5.191

2.  In vivo trypanocidal activities of new S-adenosylmethionine decarboxylase inhibitors.

Authors:  C J Bacchi; R Brun; S L Croft; K Alicea; Y Bühler
Journal:  Antimicrob Agents Chemother       Date:  1996-06       Impact factor: 5.191

3.  Alterations in ornithine decarboxylase characteristics account for tolerance of Trypanosoma brucei rhodesiense to D,L-alpha-difluoromethylornithine.

Authors:  M Iten; H Mett; A Evans; J C Enyaru; R Brun; R Kaminsky
Journal:  Antimicrob Agents Chemother       Date:  1997-09       Impact factor: 5.191

4.  Combination chemotherapy of drug-resistant Trypanosoma brucei rhodesiense infections in mice using DL-alpha-difluoromethylornithine and standard trypanocides.

Authors:  C J Bacchi; H C Nathan; N Yarlett; B Goldberg; P P McCann; A Sjoerdsma; M Saric; A B Clarkson
Journal:  Antimicrob Agents Chemother       Date:  1994-03       Impact factor: 5.191

5.  Cure of murine Trypanosoma brucei rhodesiense infections with an S-adenosylmethionine decarboxylase inhibitor.

Authors:  C J Bacchi; H C Nathan; N Yarlett; B Goldberg; P P McCann; A J Bitonti; A Sjoerdsma
Journal:  Antimicrob Agents Chemother       Date:  1992-12       Impact factor: 5.191

6.  A luciferase based viability assay for ATP detection in 384-well format for high throughput whole cell screening of Trypanosoma brucei brucei bloodstream form strain 427.

Authors:  Melissa L Sykes; Vicky M Avery
Journal:  Parasit Vectors       Date:  2009-11-12       Impact factor: 3.876

Review 7.  The Drugs of Sleeping Sickness: Their Mechanisms of Action and Resistance, and a Brief History.

Authors:  Harry P De Koning
Journal:  Trop Med Infect Dis       Date:  2020-01-19
  7 in total

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