Literature DB >> 25157983

Hypoxia inducible factors in liver disease and hepatocellular carcinoma: current understanding and future directions.

Garrick K Wilson1, Daniel A Tennant2, Jane A McKeating3.   

Abstract

Hypoxia inducible transcription factors (HIFs) activate diverse pathways that regulate cellular metabolism, angiogenesis, proliferation, and migration, enabling a cell to respond to a low oxygen or hypoxic environment. HIFs are regulated by oxygen-dependent and independent signals including: mitochondrial dysfunction, reactive oxygen species, endoplasmic reticular stress, and viral infection. HIFs have been reported to play a role in the pathogenesis of liver disease of diverse aetiologies. This review explores the impact of HIFs on hepatocellular biology and inflammatory responses, highlighting the therapeutic potential of targeting HIFs for an array of liver pathologies.
Copyright © 2014. Published by Elsevier B.V.

Entities:  

Keywords:  HIF; Hypoxia; Inflammation; Liver; Viral hepatitis

Mesh：

Substances：

Year:  2014        PMID： 25157983     DOI： 10.1016/j.jhep.2014.08.025

Source DB:  PubMed          Journal:  J Hepatol        ISSN： 0168-8278            Impact factor:   25.083


  66 in total

Review 1.  Roles of mitochondria in liver cancer stem cells.

Authors:  Ching-Wen Chang; Jeng-Fan Lo; Xin Wei Wang
Journal:  Differentiation       Date:  2019-05-30       Impact factor: 3.880

2.  Translational and transcriptional responses in human primary hepatocytes under hypoxia.

Authors:  Gaya K Hettiarachchi; Upendra K Katneni; Ryan C Hunt; Jacob M Kames; John C Athey; Haim Bar; Zuben E Sauna; Joseph R McGill; Juan C Ibla; Chava Kimchi-Sarfaty
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2019-03-28       Impact factor: 4.052

3.  Expression of proteins associated with hypoxia and Wnt pathway activation is of prognostic significance in hepatocellular carcinoma.

Authors:  Supriya Srivastava; Bhavin Thakkar; Khay Guan Yeoh; Khek Yu Ho; Ming Teh; Richie Soong; Manuel Salto-Tellez
Journal:  Virchows Arch       Date:  2015-03-06       Impact factor: 4.064

4.  Defective Beclin-1 and elevated hypoxia-inducible factor (HIF)-1α expression are closely linked to tumorigenesis, differentiation, and progression of hepatocellular carcinoma.

Authors:  Nisreen A A Osman; Dalia M Abd El-Rehim; Inas M Kamal
Journal:  Tumour Biol       Date:  2015-01-17

5.  Preclinical Benefit of Hypoxia-Activated Intra-arterial Therapy with Evofosfamide in Liver Cancer.

Authors:  Rafael Duran; Sahar Mirpour; Vasily Pekurovsky; Shanmugasundaram Ganapathy-Kanniappan; Cory F Brayton; Toby C Cornish; Boris Gorodetski; Juvenal Reyes; Julius Chapiro; Rüdiger E Schernthaner; Constantine Frangakis; MingDe Lin; Jessica D Sun; Charles P Hart; Jean-François Geschwind
Journal:  Clin Cancer Res       Date:  2016-07-20       Impact factor: 12.531

6.  Gα12 ablation exacerbates liver steatosis and obesity by suppressing USP22/SIRT1-regulated mitochondrial respiration.

Authors:  Tae Hyun Kim; Yoon Mee Yang; Chang Yeob Han; Ja Hyun Koo; Hyunhee Oh; Su Sung Kim; Byoung Hoon You; Young Hee Choi; Tae-Sik Park; Chang Ho Lee; Hitoshi Kurose; Mazen Noureddin; Ekihiro Seki; Yu-Jui Yvonne Wan; Cheol Soo Choi; Sang Geon Kim
Journal:  J Clin Invest       Date:  2018-11-12       Impact factor: 14.808

Review 7.  The immunological and metabolic landscape in primary and metastatic liver cancer.

Authors:  Xin Li; Pierluigi Ramadori; Dominik Pfister; Marco Seehawer; Lars Zender; Mathias Heikenwalder
Journal:  Nat Rev Cancer       Date:  2021-07-29       Impact factor: 60.716

Review 8.  Metabolic aspects in NAFLD, NASH and hepatocellular carcinoma: the role of PGC1 coactivators.

Authors:  Elena Piccinin; Gaetano Villani; Antonio Moschetta
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2019-03       Impact factor: 46.802

9.  Hepatitis C Virus Downregulates Ubiquitin-Conjugating Enzyme E2S Expression To Prevent Proteasomal Degradation of NS5A, Leading to Host Cells More Sensitive to DNA Damage.

Authors:  Hang T Pham; Tram T T Nguyen; Lap P Nguyen; Sang-Seop Han; Yun-Sook Lim; Soon B Hwang
Journal:  J Virol       Date:  2019-01-04       Impact factor: 5.103

10.  Is de novo hepatocellular carcinoma after transjugular intrahepatic portosystemic shunt increased?

Authors:  A Hüsing-Kabar; T Meister; M Köhler; W Domschke; I Kabar; C Wilms; B Hild; H H Schmidt; H S Heinzow
Journal:  United European Gastroenterol J       Date:  2017-09-20       Impact factor: 4.623
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