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Literature DB >> 25157643

Surface presentation of functional peptides in solution determines cell internalization efficiency of TAT conjugated nanoparticles.

Nevena Todorova¹, Ciro Chiappini, Morgan Mager, Benjamin Simona, Imran I Patel, Molly M Stevens, Irene Yarovsky.

Abstract

Functionalizing nanoparticles with cell-penetrating peptides is a popular choice for cellular delivery. We investigated the effects of TAT peptide concentration and arrangement in solution on functionalized nanoparticles' efficacy for membrane permeation. We found that cell internalization correlates with the positive charge distribution achieved prior to nanoparticle encountering interactions with membrane. We identified a combination of solution based properties required to maximize the internalization efficacy of TAT-functionalized nanoparticles.

Entities: Chemical

Keywords: Cell internalization; cell-penetrating peptides; functionalized nanoparticles; gold; molecular dynamics

Mesh：

Substances：

Year: 2014 PMID： 25157643 PMCID： PMC5408925 DOI： 10.1021/nl5021848

Source DB: PubMed Journal: Nano Lett ISSN： 1530-6984 Impact factor: 11.189

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