Literature DB >> 25157508

CLEARance wars: PolyQ strikes back.

X William Yang1, Ai Yamamoto2.   

Abstract

Polyglutamine expansion in the androgen receptor, causing X-linked spinal and bulbar muscular atrophy, impairs its function as a transcriptional coactivator regulating an extensive network of proteins involved in protein clearance.

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Year:  2014        PMID： 25157508     DOI： 10.1038/nn.3793

Source DB:  PubMed          Journal:  Nat Neurosci        ISSN： 1097-6256            Impact factor:   24.884


  14 in total

1.  Native functions of the androgen receptor are essential to pathogenesis in a Drosophila model of spinobulbar muscular atrophy.

Authors:  Natalia B Nedelsky; Maria Pennuto; Rebecca B Smith; Isabella Palazzolo; Jennifer Moore; Zhiping Nie; Geoffrey Neale; J Paul Taylor
Journal:  Neuron       Date:  2010-09-23       Impact factor: 17.173

Review 2.  Trinucleotide repeat disorders.

Authors:  Harry T Orr; Huda Y Zoghbi
Journal:  Annu Rev Neurosci       Date:  2007       Impact factor: 12.449

3.  Transcriptional activation of TFEB/ZKSCAN3 target genes underlies enhanced autophagy in spinobulbar muscular atrophy.

Authors:  Jason P Chua; Satya L Reddy; Diane E Merry; Hiroaki Adachi; Masahisa Katsuno; Gen Sobue; Diane M Robins; Andrew P Lieberman
Journal:  Hum Mol Genet       Date:  2013-10-22       Impact factor: 6.150

4.  Androgen-dependent neurodegeneration by polyglutamine-expanded human androgen receptor in Drosophila.

Authors:  Ken-ichi Takeyama; Saya Ito; Ayako Yamamoto; Hiromu Tanimoto; Takashi Furutani; Hirotaka Kanuka; Masayuki Miura; Tetsuya Tabata; Shigeaki Kato
Journal:  Neuron       Date:  2002-08-29       Impact factor: 17.173

5.  Testosterone reduction prevents phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy.

Authors:  Masahisa Katsuno; Hiroaki Adachi; Akito Kume; Mei Li; Yuji Nakagomi; Hisayoshi Niwa; Chen Sang; Yasushi Kobayashi; Manabu Doyu; Gen Sobue
Journal:  Neuron       Date:  2002-08-29       Impact factor: 17.173

6.  PGC-1α rescues Huntington's disease proteotoxicity by preventing oxidative stress and promoting TFEB function.

Authors:  Taiji Tsunemi; Travis D Ashe; Bradley E Morrison; Kathryn R Soriano; Jonathan Au; Ruben A Vázquez Roque; Eduardo R Lazarowski; Vincent A Damian; Eliezer Masliah; Albert R La Spada
Journal:  Sci Transl Med       Date:  2012-07-11       Impact factor: 17.956

7.  TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity.

Authors:  Mickael Decressac; Bengt Mattsson; Pia Weikop; Martin Lundblad; Johan Jakobsson; Anders Björklund
Journal:  Proc Natl Acad Sci U S A       Date:  2013-04-22       Impact factor: 11.205

8.  Peripheral androgen receptor gene suppression rescues disease in mouse models of spinal and bulbar muscular atrophy.

Authors:  Andrew P Lieberman; Zhigang Yu; Sue Murray; Raechel Peralta; Audrey Low; Shuling Guo; Xing Xian Yu; Constanza J Cortes; C Frank Bennett; Brett P Monia; Albert R La Spada; Gene Hung
Journal:  Cell Rep       Date:  2014-04-16       Impact factor: 9.423

9.  Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1.

Authors:  Janghoo Lim; Juan Crespo-Barreto; Paymaan Jafar-Nejad; Aaron B Bowman; Ronald Richman; David E Hill; Harry T Orr; Huda Y Zoghbi
Journal:  Nature       Date:  2008-03-12       Impact factor: 49.962

10.  Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA.

Authors:  Constanza J Cortes; Helen C Miranda; Harald Frankowski; Yakup Batlevi; Jessica E Young; Amy Le; Nishi Ivanov; Bryce L Sopher; Cassiano Carromeu; Alysson R Muotri; Gwenn A Garden; Albert R La Spada
Journal:  Nat Neurosci       Date:  2014-08-10       Impact factor: 24.884
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  2 in total

Review 1.  Autophagy in polyglutamine disease: Imposing order on disorder or contributing to the chaos?

Authors:  Constanza J Cortes; Albert R La Spada
Journal:  Mol Cell Neurosci       Date:  2015-03-11       Impact factor: 4.314

2.  ATXN2 trinucleotide repeat length correlates with risk of ALS.

Authors:  William Sproviero; Aleksey Shatunov; Daniel Stahl; Maryam Shoai; Wouter van Rheenen; Ashley R Jones; Safa Al-Sarraj; Peter M Andersen; Nancy M Bonini; Francesca L Conforti; Philip Van Damme; Hussein Daoud; Maria Del Mar Amador; Isabella Fogh; Monica Forzan; Ben Gaastra; Cinzia Gellera; Aaron D Gitler; John Hardy; Pietro Fratta; Vincenzo La Bella; Isabelle Le Ber; Tim Van Langenhove; Serena Lattante; Yi-Chung Lee; Andrea Malaspina; Vincent Meininger; Stéphanie Millecamps; Richard Orrell; Rosa Rademakers; Wim Robberecht; Guy Rouleau; Owen A Ross; Francois Salachas; Katie Sidle; Bradley N Smith; Bing-Wen Soong; Gianni Sorarù; Giovanni Stevanin; Edor Kabashi; Claire Troakes; Christine van Broeckhoven; Jan H Veldink; Leonard H van den Berg; Christopher E Shaw; John F Powell; Ammar Al-Chalabi
Journal:  Neurobiol Aging       Date:  2016-11-24       Impact factor: 5.133
  2 in total

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