Literature DB >> 25156908

Modified poly(lactic-co-glycolic acid) nanoparticles for enhanced cellular uptake and gene editing in the lung.

Rachel J Fields1, Elias Quijano, Nicole Ali McNeer, Christina Caputo, Raman Bahal, Kavi Anandalingam, Marie E Egan, Peter M Glazer, W Mark Saltzman.   

Abstract

Surface-modified poly(lactic-co-glycolic acid) (PLGA)/poly(β-aminoester)(PBAE)nanoparticles (NPs) have shown great promise in gene delivery. In this work, the pulmonary cellular uptake of these NPs is evaluated and surface-modified PLGA/PBAE NPs are shown to achieve higher cellular association and gene editing than traditional NPs composed of PLGA or PLGA/PBAE blends alone.
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  cell-penetrating peptide; cellular uptake; gene editing; nanoparticles; pulmonary delivery

Mesh：

Substances：

Year:  2014        PMID： 25156908      PMCID： PMC4339402          DOI： 10.1002/adhm.201400355

Source DB:  PubMed          Journal:  Adv Healthc Mater        ISSN： 2192-2640            Impact factor:   9.933


  30 in total

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  14 in total

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