Aritoshi Hattori1, Kenji Suzuki2, Keiju Aokage3, Takahiro Mimae4, Kanji Nagai3, Masahiro Tsuboi3, Morihito Okada4. 1. Department of General Thoracic Surgery, Juntendo University School of Medicine, Tokyo. 2. Department of General Thoracic Surgery, Juntendo University School of Medicine, Tokyo kjsuzuki@juntendo.ac.jp. 3. Division of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, Chiba. 4. Department of Surgical Oncology, Hiroshima University, Hiroshima, Japan.
Abstract
OBJECTIVES: The prognosis in lung cancer patients with a prior history of extrapulmonary cancer is controversial. In the current multicenter joint research in Japan, we focused on the relationship between a history of colorectal cancer and its prognostic impact in patients with subsequent lung cancer. METHODS: Between 2000 and 2013, we designed a retrospective multicenter study at three institutes in Japan to evaluate the prognostic factors in lung cancer patients with a previous surgery for colorectal cancer. RESULTS: The cohorts consisted of 123/4431 lung cancer patients with/without a previous history of surgery for colorectal cancer. The median follow-up period was 6.1 years after lung cancer surgery. The 5-year overall survival in lung cancer patients with/without colorectal cancer was not significantly different, regardless of the stage of lung cancer (overall: 71.3 versus 74.7%, P = 0.1426; Stage I lung cancer: 83.3 versus 84.8%, P = 0.3779; Stage II or more lung cancer: 47.7 versus 54.4%, P = 0.1445). Based on multivariate Cox regression analysis in 4554 lung cancer patients, a past history of colorectal cancer was not a significant prognostic factor (P = 0.5335). Among the 123 lung cancer patients with colorectal cancer, age and absence of adjuvant chemotherapy for colorectal cancer were significant prognostic factors based on multivariate analysis (P = 0.0001 and 0.0236). Furthermore, there was no difference in the overall survival of lung cancer patients according to the stage of colorectal cancer (Stage I: 74.7%; Stage II/III: 66.5%, P = 0.7239). CONCLUSIONS: A history of antecedent colorectal cancer did not contribute to the prognosis in patients with subsequent lung cancers.
OBJECTIVES: The prognosis in lung cancerpatients with a prior history of extrapulmonary cancer is controversial. In the current multicenter joint research in Japan, we focused on the relationship between a history of colorectal cancer and its prognostic impact in patients with subsequent lung cancer. METHODS: Between 2000 and 2013, we designed a retrospective multicenter study at three institutes in Japan to evaluate the prognostic factors in lung cancerpatients with a previous surgery for colorectal cancer. RESULTS: The cohorts consisted of 123/4431 lung cancerpatients with/without a previous history of surgery for colorectal cancer. The median follow-up period was 6.1 years after lung cancer surgery. The 5-year overall survival in lung cancerpatients with/without colorectal cancer was not significantly different, regardless of the stage of lung cancer (overall: 71.3 versus 74.7%, P = 0.1426; Stage I lung cancer: 83.3 versus 84.8%, P = 0.3779; Stage II or more lung cancer: 47.7 versus 54.4%, P = 0.1445). Based on multivariate Cox regression analysis in 4554 lung cancerpatients, a past history of colorectal cancer was not a significant prognostic factor (P = 0.5335). Among the 123 lung cancerpatients with colorectal cancer, age and absence of adjuvant chemotherapy for colorectal cancer were significant prognostic factors based on multivariate analysis (P = 0.0001 and 0.0236). Furthermore, there was no difference in the overall survival of lung cancerpatients according to the stage of colorectal cancer (Stage I: 74.7%; Stage II/III: 66.5%, P = 0.7239). CONCLUSIONS: A history of antecedent colorectal cancer did not contribute to the prognosis in patients with subsequent lung cancers.