Ran Xu1, Hai-Qin Xie1, Lu-Lu Deng1, Jian-Xin Zhang1, Fu-Mei Yang1, Jian-Hua Liu1, Xiao-Jiang Hao1, Yuan-Hu Zhang2. 1. The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, China. 2. The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, China. Electronic address: zhangyuanhu@263.net.
Abstract
AIM: To study the bufadienolides in the Chinese traditional drug "Ch'an Su" and their cytotoxic activity. METHOD: Various chromatographic techniques were used to isolate the constituents, and their structures were elucidated through physical and spectroscopic data. RESULTS: Twenty compounds were isolated, and eighteen were evaluated in vitro for their cytotoxic activity against A-549 and K-562 cells. CONCLUSION: Compound 1 (bufalin 3β-acrylic ester) was a new bufadienolide and exhibited the most potent activity against the two tumor cell lines with IC50 values of 7.16 and 6.83 nmol · L(-1). The relationships between structure and activity are discussed.
AIM: To study the bufadienolides in the Chinese traditional drug "Ch'an Su" and their cytotoxic activity. METHOD: Various chromatographic techniques were used to isolate the constituents, and their structures were elucidated through physical and spectroscopic data. RESULTS: Twenty compounds were isolated, and eighteen were evaluated in vitro for their cytotoxic activity against A-549 and K-562 cells. CONCLUSION: Compound 1 (bufalin 3β-acrylic ester) was a new bufadienolide and exhibited the most potent activity against the two tumor cell lines with IC50 values of 7.16 and 6.83 nmol · L(-1). The relationships between structure and activity are discussed.
Authors: Guillermo Schmeda-Hirschmann; Jean Paulo de Andrade; Marilú Roxana Soto-Vasquez; Paul Alan Arkin Alvarado-García; Charlotte Palominos; Sebastián Fuentes-Retamal; Mathias Mellado; Pablo Correa; Félix A Urra Journal: Toxins (Basel) Date: 2020-09-22 Impact factor: 4.546