AIM: Determine whether SNPs of OPRM1 118A>G (asn(40)asp), COMT 472G>A (val(158)met) and ARRB2 8622C>T are associated with morphine rescue in newborns on mechanical ventilation. MATERIALS & METHODS: This is a pharmacogenetic analysis of a randomized controlled trial in (pre)term newborns (n = 64) at a level III Neonatal Intensive Care Unit (NICU) who receivedplacebo infusion and for whom need and dose for rescue morphine was documented. RESULTS: For OPRM1 and COMT separately, the expected risk for rescue morphine or morphine dose was not significantly increased. However, the combined OPRM1/COMT 'high-risk' genotype lead to a significant association with the need for rescue (OR: 5.12; 95% CI: 1.12-23.3; p = 0.035). No association was found between OPRM1/COMT 'high-risk' genotype and total morphine dose administered. CONCLUSION: Combined OPRM1 118A>G and COMT 472G>A genotype might serve as a predictor for the need of rescue morphine in premature and term newborns on mechanical ventilation.
RCT Entities:
AIM: Determine whether SNPs of OPRM1 118A>G (asn(40)asp), COMT 472G>A (val(158)met) and ARRB2 8622C>T are associated with morphine rescue in newborns on mechanical ventilation. MATERIALS & METHODS: This is a pharmacogenetic analysis of a randomized controlled trial in (pre)term newborns (n = 64) at a level III Neonatal Intensive Care Unit (NICU) who received placebo infusion and for whom need and dose for rescue morphine was documented. RESULTS: For OPRM1 and COMT separately, the expected risk for rescue morphine or morphine dose was not significantly increased. However, the combined OPRM1/COMT 'high-risk' genotype lead to a significant association with the need for rescue (OR: 5.12; 95% CI: 1.12-23.3; p = 0.035). No association was found between OPRM1/COMT 'high-risk' genotype and total morphine dose administered. CONCLUSION: Combined OPRM1 118A>G and COMT 472G>A genotype might serve as a predictor for the need of rescue morphine in premature and term newborns on mechanical ventilation.
Authors: Joshua C Euteneuer; Suyog Kamatkar; Tsuyoshi Fukuda; Alexander A Vinks; Henry T Akinbi Journal: J Clin Pharmacol Date: 2018-09-11 Impact factor: 3.126
Authors: Elizabeth M J Lee; Karen Xu; Emma Mosbrook; Amanda Links; Jessica Guzman; David R Adams; Elise Flynn; Elise Valkanas; Camillo Toro; Cynthia J Tifft; Cornelius F Boerkoel; William A Gahl; Murat Sincan Journal: Genet Med Date: 2016-06-02 Impact factor: 8.822
Authors: Cecil M Y Chau; Colin J D Ross; Vann Chau; Anne R Synnes; Steven P Miller; Bruce Carleton; Ruth E Grunau Journal: EBioMedicine Date: 2019-01-30 Impact factor: 8.143