Literature DB >> 25155489

Pulmonary leucostasis syndrome presented by unilateral pulmonary infiltrates.

Ronald Jan Trof1, Ron Schaafsma2, Bert Beishuizen1.   

Abstract

A 48-year-old woman presented with suspected acute myelogenous leukaemia with a leucocyte count of 80×10(9)/L. On admission, she had high fever and shortness of breath. Chest X-ray demonstrated unilateral consolidations of right lung suggestive for pneumonia and broad spectrum antibiotics were started. Her condition rapidly deteriorated and despite the clinical diagnosis of pulmonary leucostasis and treatment with leucapheresis the patient died within 2 days after admission from progressive respiratory failure and multiorgan failure. Autopsy showed diffuse leucostasis in the pulmonary capillaries. The present case illustrates that pulmonary leucostasis may be presented by unilateral chest X-ray abnormalities and without clear neurological symptoms (headache and blurred vision). Clinicians should be aware of this since delayed treatment may increase mortality. 2014 BMJ Publishing Group Ltd.

Entities:  

Mesh:

Year:  2014        PMID: 25155489      PMCID: PMC4153999          DOI: 10.1136/bcr-2014-204934

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  9 in total

1.  Oxygen radicals mediate endothelial cell damage by complement-stimulated granulocytes. An in vitro model of immune vascular damage.

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Journal:  J Clin Invest       Date:  1978-05       Impact factor: 14.808

Review 2.  Hyperleukocytosis, leukostasis and leukapheresis: practice management.

Authors:  Chezi Ganzel; Joanne Becker; Paul D Mintz; Hillard M Lazarus; Jacob M Rowe
Journal:  Blood Rev       Date:  2012-02-23       Impact factor: 8.250

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Authors:  J P Vernant; B Brun; P Mannoni; B Dreyfus
Journal:  Cancer       Date:  1979-07       Impact factor: 6.860

4.  High-voltage irradiation and hydroxyurea for pulmonary leukostasis in acute myelomonocytic leukemia.

Authors:  F E von Eyben; M Z Siddiqui; G Spanos
Journal:  Acta Haematol       Date:  1987       Impact factor: 2.195

Review 5.  Hyperleukocytic leukemias and leukostasis: a review of pathophysiology, clinical presentation and management.

Authors:  P Porcu; L D Cripe; E W Ng; S Bhatia; C M Danielson; A Orazi; L J McCarthy
Journal:  Leuk Lymphoma       Date:  2000-09

Review 6.  Oncologic emergencies: Pathophysiology, presentation, diagnosis, and treatment.

Authors:  Mark A Lewis; Andrea Wahner Hendrickson; Timothy J Moynihan
Journal:  CA Cancer J Clin       Date:  2011-08-19       Impact factor: 508.702

7.  Pulmonary leukostasis: radiologic-pathologic study.

Authors:  M A van Buchem; J H Wondergem; L J Kool; J te Velde; P M Kluin; P J Bode; D L Busscher
Journal:  Radiology       Date:  1987-12       Impact factor: 11.105

8.  Pulmonary leukostasis as the single worst prognostic factor in patients with acute myelocytic leukemia and hyperleukocytosis.

Authors:  T J Lester; J W Johnson; J Cuttner
Journal:  Am J Med       Date:  1985-07       Impact factor: 4.965

9.  Cranial irradiation in adults diagnosed with acute myelogenous leukemia presenting with hyperleukocytosis and neurologic dysfunction.

Authors:  Adam Ferro; Salma K Jabbour; Neil K Taunk; Joseph Aisner; Alan Cohler; Sanaa Somalya; Sharad Goyal
Journal:  Leuk Lymphoma       Date:  2013-06-04
  9 in total

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