Literature DB >> 25155488

Fatal cardiac involvement complicating antisynthetase syndrome.

Stefen Brady1, Sunil Melath2, Renata S Scalco1, Henry Penn2.   

Abstract

A 35-year-old Afro-Caribbean woman presented with dyspnoea, urticarial rash and myalgia 1 month after treatment for a community-acquired respiratory tract infection. Investigations revealed raised antisynthetase antibodies, lung fibrosis and an inflammatory myopathy. The patient was diagnosed with antisynthetase syndrome (ASS) and started on immunosuppressive medication. Despite treatment she died 4 weeks after presentation from a fulminant cardiomyopathy. ASS is a rare condition and is not typically associated with a cardiomyopathy. This case report intends to raise awareness that cardiomyopathy is a potentially fatal complication of ASS. 2014 BMJ Publishing Group Ltd.

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Mesh：

Year:  2014        PMID： 25155488      PMCID： PMC4154036          DOI： 10.1136/bcr-2014-204409

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN： 1757-790X


  6 in total

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Journal:  Curr Opin Rheumatol       Date:  2011-11       Impact factor: 5.006

2.  Hierarchical cluster and survival analyses of antisynthetase syndrome: phenotype and outcome are correlated with anti-tRNA synthetase antibody specificity.

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Journal:  Autoimmun Rev       Date:  2012-07-05       Impact factor: 9.754

Review 3.  Effects of corticosteroids and immunosuppressors on idiopathic inflammatory myopathy related myocarditis evaluated by magnetic resonance imaging.

Authors:  Y Allanore; O Vignaux; L Arnaud; X Puéchal; S Pavy; D Duboc; P Legmann; A Kahan
Journal:  Ann Rheum Dis       Date:  2006-02       Impact factor: 19.103

4.  Cardiac involvement in polymyositis: a clinicopathologic study of 20 autopsied patients.

Authors:  C E Denbow; J T Lie; R G Tancredi; T W Bunch
Journal:  Arthritis Rheum       Date:  1979-10

5.  The heart and cardiac conduction system in polymyositis-dermatomyositis: a clinicopathologic study of 16 autopsied patients.

Authors:  H M Haupt; G M Hutchins
Journal:  Am J Cardiol       Date:  1982-11       Impact factor: 2.778

Review 6.  Novel autoantibodies and clinical phenotypes in adult and juvenile myositis.

Authors:  Zoe E Betteridge; Harsha Gunawardena; Neil J McHugh
Journal:  Arthritis Res Ther       Date:  2011-03-18       Impact factor: 5.156
  6 in total
  2 in total

1.  Myocarditis in Patients With Antisynthetase Syndrome: Prevalence, Presentation, and Outcomes.

Authors:  Céline Dieval; Christophe Deligny; Alain Meyer; Philippe Cluzel; Nicolas Champtiaux; Guillaume Lefevre; David Saadoun; Jean Sibilia; Jean-Luc Pellegrin; Eric Hachulla; Olivier Benveniste; Baptiste Hervier
Journal:  Medicine (Baltimore)       Date:  2015-07       Impact factor: 1.889

2.  Anti-Aminoacyl Transfer-RNA-Synthetases (Anti-tRNA) Autoantibodies Associated with Interstitial Lung Disease: Pulmonary Disease Progression has a Persistent Elevation of the Th17 Cytokine Profile.

Authors:  Espiridión Ramos-Martinez; Ramcés Falfán-Valencia; Gloria Pérez-Rubio; Mayra Mejia; Ivette Buendía-Roldán; Montserrat I González-Pérez; Heidegger N Mateos-Toledo; Jorge Rojas Serrano
Journal:  J Clin Med       Date:  2020-05-06       Impact factor: 4.241
  2 in total

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