Literature DB >> 25154389

Decrease of 5-hydroxymethylcytosine in rat liver with subchronic exposure to genotoxic carcinogens riddelliine and aristolochic acid.

Christine Guo Lian1, Shuyun Xu1, Weimin Guo1, Jian Yan2, Maximilian Y M Frank1, Robert Liu1, Cynthia Liu1, Ying Chen2, George F Murphy1, Tao Chen2.   

Abstract

The level of 5-hydroxymethylcytosine (5-hmC) converted by ten-eleven translocation (TET) family is decreased in cancers. However, whether 5-hmC level is perturbed in early stages of carcinogenesis caused by genotoxic carcinogens is not defined. 5-hmC levels and TET2 expression were measured in liver of rats treated with genotoxic carcinogens, riddelliine, or aristolochic acid. Levels of 5-hmC and TET2 expression decreased in the liver of the carcinogens-treated rats. Loss of 5-hmC correlates well with documented induction of genetic mutations by the carcinogens, suggesting that TET2-mediated 5-hydroxymethylation plays an epigenetic role in early state of carcinogenesis.
© 2014 Wiley Periodicals, Inc.

Entities:  

Keywords:  5-hydroxymethylcytosine; aristolochic acid; carcinogenesis; mutagenesis; riddelliine; ten-eleven translocation

Mesh：

Substances：

Year:  2014        PMID： 25154389      PMCID： PMC5832966          DOI： 10.1002/mc.22201

Source DB:  PubMed          Journal:  Mol Carcinog        ISSN： 0899-1987            Impact factor:   4.784


  19 in total

1.  Aristolochic acid-induced carcinogenesis examined by ACB-PCR quantification of H-Ras and K-Ras mutant fraction.

Authors:  Yiying Wang; Fanxue Meng; Volker M Arlt; Nan Mei; Tao Chen; Barbara L Parsons
Journal:  Mutagenesis       Date:  2011-06-03       Impact factor: 3.000

Review 2.  Pyrrolizidine alkaloids in food: a spectrum of potential health consequences.

Authors:  J A Edgar; S M Colegate; M Boppré; R J Molyneux
Journal:  Food Addit Contam Part A Chem Anal Control Expo Risk Assess       Date:  2011-03

3.  Toxicology and carcinogenesis studies of riddelliine (CAS No. 23246-96-0) in F344/N rats and B6C3F1 mice (gavage studies).

Authors: 
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4.  Mutations induced by the carcinogenic pyrrolizidine alkaloid riddelliine in the liver cII gene of transgenic big blue rats.

Authors:  Nan Mei; Robert H Heflich; Ming W Chou; Tao Chen
Journal:  Chem Res Toxicol       Date:  2004-06       Impact factor: 3.739

5.  Chemical-specific alterations in ras, p53, and beta-catenin genes in hemangiosarcomas from B6C3F1 mice exposed to o-nitrotoluene or riddelliine for 2 years.

Authors:  H L Hong; T V Ton; T R Devereux; C Moomaw; N Clayton; P Chan; J K Dunnick; R C Sills
Journal:  Toxicol Appl Pharmacol       Date:  2003-09-15       Impact factor: 4.219

6.  Toxicity and carcinogenicity of riddelliine in rats and mice.

Authors:  Po C Chan; Joseph K Haseman; J D Prejean; Abraham Nyska
Journal:  Toxicol Lett       Date:  2003-10-15       Impact factor: 4.372

Review 7.  Tet family proteins and 5-hydroxymethylcytosine in development and disease.

Authors:  Li Tan; Yujiang Geno Shi
Journal:  Development       Date:  2012-06       Impact factor: 6.868

Review 8.  Non-canonical functions of the DNA methylome in gene regulation.

Authors:  James P Reddington; Sari Pennings; Richard R Meehan
Journal:  Biochem J       Date:  2013-04-01       Impact factor: 3.857

9.  Non-genotoxic carcinogen exposure induces defined changes in the 5-hydroxymethylome.

Authors:  John P Thomson; Harri Lempiäinen; Jamie A Hackett; Colm E Nestor; Arne Müller; Federico Bolognani; Edward J Oakeley; Dirk Schübeler; Rémi Terranova; Diana Reinhardt; Jonathan G Moggs; Richard R Meehan
Journal:  Genome Biol       Date:  2012-10-03       Impact factor: 13.583

10.  Decrease of 5-hydroxymethylcytosine is associated with progression of hepatocellular carcinoma through downregulation of TET1.

Authors:  Chungang Liu; Limei Liu; Xuejiao Chen; Junjie Shen; Juanjuan Shan; Yanmin Xu; Zhi Yang; Lin Wu; Feng Xia; Ping Bie; Youhong Cui; Xiu-wu Bian; Cheng Qian
Journal:  PLoS One       Date:  2013-05-09       Impact factor: 3.240
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  3 in total

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Authors:  Evgeniy Stoyanov; Guy Ludwig; Lina Mizrahi; Devorah Olam; Temima Schnitzer-Perlman; Elena Tasika; Gabriele Sass; Gisa Tiegs; Yong Jiang; Ting Nie; James Kohler; Raymond F Schinazi; Paula M Vertino; Howard Cedar; Eithan Galun; Daniel Goldenberg
Journal:  Oncotarget       Date:  2015-05-10

2.  Loss of Tet1-Associated 5-Hydroxymethylcytosine Is Concomitant with Aberrant Promoter Hypermethylation in Liver Cancer.

Authors:  John P Thomson; Raffaele Ottaviano; Elif B Unterberger; Harri Lempiäinen; Arne Muller; Remi Terranova; Robert S Illingworth; Shaun Webb; Alastair R W Kerr; Marcus J Lyall; Amanda J Drake; C Roland Wolf; Jonathan G Moggs; Michael Schwarz; Richard R Meehan
Journal:  Cancer Res       Date:  2016-04-06       Impact factor: 12.701

3.  Defining baseline epigenetic landscapes in the rat liver.

Authors:  John P Thomson; Raffaele Ottaviano; Roland Buesen; Jonathan G Moggs; Michael Schwarz; Richard R Meehan
Journal:  Epigenomics       Date:  2017-11-13       Impact factor: 4.778
  3 in total

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