| Literature DB >> 25151974 |
Ram Pyare Singh1, Sascha Hasan2, Sherven Sharma3, Saranpreet Nagra4, Dean T Yamaguchi3, David T W Wong5, Bevra H Hahn4, Awlad Hossain4.
Abstract
T helper 17 (Th17), a distinct subset of CD4(+) T cells with IL-17 as their major cytokine, orchestrate the pathogenesis of inflammatory and autoimmune diseases. Dysregulated Th17 cells contribute to inflammatory and autoimmune diseases. Candidate biologics are in development for targeting IL-17, IL-17 receptors or IL-17 pathways. Several drugs that impact the IL-17 pathway are already in clinical trials for the treatment of autoimmune diseases. In this review we provide evidence for the role of Th17 cells in immune-mediated diseases. An understanding of the role of Th17 in these conditions will provide important insights and unravel novel targets for therapeutic intervention.Entities:
Keywords: Autoimmunity; Cancer; Mesenchymal stem cells; Sex hormones; Systemic lupus erythematosus; Th17
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Year: 2014 PMID： 25151974 DOI： 10.1016/j.autrev.2014.08.019
Source DB: PubMed Journal: Autoimmun Rev ISSN： 1568-9972 Impact factor: 9.754