Literature DB >> 2515176

Secretion of transforming growth factor-beta by human myelogenous leukemic cells and its possible role in proliferation of the leukemic cells.

K Komatsu1, H Nakamura, K Shinkai, H Akedo.   

Abstract

Transforming growth factor (TGF)-beta activity was found in the neutral extracts of human myelogenous leukemic cells or K562 cells and the conditioned medium from K562 cell culture. BALB/c 3T3 cells grown in soft agar in the presence of TGF-beta 1 produced an activity that stimulated the growth of K562 cells. This activity was non-dialyzable, acid-stable, heat-sensitive and partially inactivated by pronase treatment. These results suggest a mutual growth reliance between the leukemic cells and fibroblasts mediated by paracrine growth factors produced by these cells.

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Year:  1989        PMID： 2515176      PMCID： PMC5917882          DOI： 10.1111/j.1349-7006.1989.tb01628.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  13 in total

Review 1.  Haemopoietic growth factors 1.

Authors:  D Metcalf
Journal:  Lancet       Date:  1989-04-15       Impact factor: 79.321

2.  Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro.

Authors:  A B Roberts; M B Sporn; R K Assoian; J M Smith; N S Roche; L M Wakefield; U I Heine; L A Liotta; V Falanga; J H Kehrl
Journal:  Proc Natl Acad Sci U S A       Date:  1986-06       Impact factor: 11.205

3.  [A transforming growth factor from human myelogenous leukemic cells].

Authors:  H Nakamura; K Komatsu; H Teshima; A Hiraoka; H Shibata; T Masaoka
Journal:  Rinsho Ketsueki       Date:  1987-08

4.  Growth factors in chronic myelogenous leukemia.

Authors:  V Kothari; S H Advani; S G Rao
Journal:  Cancer Lett       Date:  1986-09       Impact factor: 8.679

Review 5.  Transforming growth factor beta regulation of cell proliferation.

Authors:  H L Moses; R J Coffey; E B Leof; R M Lyons; J Keski-Oja
Journal:  J Cell Physiol Suppl       Date:  1987

6.  Dissecting the hematopoietic microenvironment. III. Evidence for a positive short range stimulus for cellular proliferation.

Authors:  N S Wolf
Journal:  Cell Tissue Kinet       Date:  1978-07

7.  Human myeloid leukemic cell (HL-60) autostimulator: relationship to colony-stimulating factor.

Authors:  S L Perkins; P E Andreotti; S K Sinha; M C Wu; A A Yunis
Journal:  Cancer Res       Date:  1984-11       Impact factor: 12.701

8.  Transforming growth factors from neoplastic and nonneoplastic tissues.

Authors:  A B Roberts; C A Frolik; M A Anzano; M B Sporn
Journal:  Fed Proc       Date:  1983-06

9.  Stromal cell-dependent growth of leukemic cells from murine erythroblastic leukemia.

Authors:  K Itoh; R Sasaki; K Ono; H Tezuka; H Sakoda; H Sawada; K Hitomi; H Nakane; T Uchiyama; H Uchino
Journal:  Jpn J Cancer Res       Date:  1988-08

10.  Stimulation of the chemotactic migration of human fibroblasts by transforming growth factor beta.

Authors:  A E Postlethwaite; J Keski-Oja; H L Moses; A H Kang
Journal:  J Exp Med       Date:  1987-01-01       Impact factor: 14.307
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  2 in total

1.  Gene expression of cytokines suppressing hematopoietic progenitor cells in lymphoid malignancies.

Authors:  C Kawasaki; S Okamura; S Hayashi; S Kondo; M Harada; Y Niho
Journal:  J Cancer Res Clin Oncol       Date:  1991       Impact factor: 4.553

2.  The inhibitory effect caused by suramin on the paracrine growth of human cancer cells and fibroblasts.

Authors:  H Mukaida; N Hirabayashi; T Hirai; Y Yamashita; T Iwata; S Saeki; T Toge
Journal:  Surg Today       Date:  1994       Impact factor: 2.549
  2 in total

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