Literature DB >> 25151002

A method for the generation of TCR retrogenic mice.

Elisa Kieback1, Ellen Hilgenberg, Simon Fillatreau.   

Abstract

Retrogenic mice provide a unique system for rapidly analyzing the function of genes in the hematopoietic system. Here, we provide a detailed protocol for the production of retrogenic mice expressing genes coding for T cell receptor (TCR) for antigen. This technology should be easy to establish in any laboratory and should allow for a rapid progress in our understanding of the functional roles of TCR repertoires in immunity.

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Year:  2014        PMID: 25151002     DOI: 10.1007/978-1-4939-1212-4_12

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN: 1064-3745


  1 in total

Review 1.  Antigen-Specificity in the Thymic Development and Peripheral Activity of CD4+FOXP3+ T Regulatory Cells.

Authors:  Jelka Pohar; Quentin Simon; Simon Fillatreau
Journal:  Front Immunol       Date:  2018-07-23       Impact factor: 7.561

  1 in total

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