Literature DB >> 25150565

Genetics of obsessive-compulsive disorder and related disorders.

Heidi A Browne1, Shannon L Gair2, Jeremiah M Scharf3, Dorothy E Grice4.   

Abstract

Twin and family studies support a significant genetic contribution to obsessive-compulsive disorder (OCD) and related disorders, such as chronic tic disorders, trichotillomania, skin-picking disorder, body dysmorphic disorder, and hoarding disorder. Recently, population-based studies and novel laboratory-based methods have confirmed substantial heritability in OCD. Genome-wide association studies and candidate gene association studies have provided information on specific gene variations that may be involved in the pathobiology of OCD, though a substantial portion of the genetic risk architecture remains unknown.
Copyright © 2014 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Candidate gene; Familial recurrence; GWAS; Genetics; Heritability; Model system; OCD; Twin study

Mesh：

Year:  2014        PMID： 25150565      PMCID： PMC4143777          DOI： 10.1016/j.psc.2014.06.002

Source DB:  PubMed          Journal:  Psychiatr Clin North Am        ISSN： 0193-953X


  93 in total

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Authors:  Heidi A Browne; Stefan N Hansen; Joseph D Buxbaum; Shannon L Gair; Judith B Nissen; Kathrine H Nikolajsen; Diana E Schendel; Abraham Reichenberg; Erik T Parner; Dorothy E Grice
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7.  Common variants on chromosome 6p22.1 are associated with schizophrenia.

Authors:  Jianxin Shi; Douglas F Levinson; Jubao Duan; Alan R Sanders; Yonglan Zheng; Itsik Pe'er; Frank Dudbridge; Peter A Holmans; Alice S Whittemore; Bryan J Mowry; Ann Olincy; Farooq Amin; C Robert Cloninger; Jeremy M Silverman; Nancy G Buccola; William F Byerley; Donald W Black; Raymond R Crowe; Jorge R Oksenberg; Daniel B Mirel; Kenneth S Kendler; Robert Freedman; Pablo V Gejman
Journal:  Nature       Date:  2009-07-01       Impact factor: 49.962

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Authors:  S E Stewart; D Yu; J M Scharf; B M Neale; J A Fagerness; C A Mathews; P D Arnold; P D Evans; E R Gamazon; L K Davis; L Osiecki; L McGrath; S Haddad; J Crane; D Hezel; C Illman; C Mayerfeld; A Konkashbaev; C Liu; A Pluzhnikov; A Tikhomirov; C K Edlund; S L Rauch; R Moessner; P Falkai; W Maier; S Ruhrmann; H-J Grabe; L Lennertz; M Wagner; L Bellodi; M C Cavallini; M A Richter; E H Cook; J L Kennedy; D Rosenberg; D J Stein; S M J Hemmings; C Lochner; A Azzam; D A Chavira; E Fournier; H Garrido; B Sheppard; P Umaña; D L Murphy; J R Wendland; J Veenstra-VanderWeele; D Denys; R Blom; D Deforce; F Van Nieuwerburgh; H G M Westenberg; S Walitza; K Egberts; T Renner; E C Miguel; C Cappi; A G Hounie; M Conceição do Rosário; A S Sampaio; H Vallada; H Nicolini; N Lanzagorta; B Camarena; R Delorme; M Leboyer; C N Pato; M T Pato; E Voyiaziakis; P Heutink; D C Cath; D Posthuma; J H Smit; J Samuels; O J Bienvenu; B Cullen; A J Fyer; M A Grados; B D Greenberg; J T McCracken; M A Riddle; Y Wang; V Coric; J F Leckman; M Bloch; C Pittenger; V Eapen; D W Black; R A Ophoff; E Strengman; D Cusi; M Turiel; F Frau; F Macciardi; J R Gibbs; M R Cookson; A Singleton; J Hardy; A T Crenshaw; M A Parkin; D B Mirel; D V Conti; S Purcell; G Nestadt; G L Hanna; M A Jenike; J A Knowles; N Cox; D L Pauls
Journal:  Mol Psychiatry       Date:  2012-08-14       Impact factor: 15.992
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