Literature DB >> 2515045

Position-effect variegation and intercalary heterochromatin: a comparative study.

I F Zhimulev1, E S Belyaeva, V N Bolshakov, N I Mal'ceva.   

Abstract

The behaviour of IH (intercalary heterochromatin) regions of Drosophila melanogaster polytene chromosomes was compared with that of euchromatin condensed as a result of position-effect variegation. Normally replicating regions, when subject to such an effect, were found to become among the last regions in the genome to replicate. It is shown that the factors which enhance position effect (low temperature, the removal of the Y chromosome, genetic enhancers of position effect) increase the weak point frequency in the IH, i.e. enhance DNA underreplication in these regions. We suggest that the similarity in the properties of IH, CH (centromeric heterochromatin) and the dense blocks induced by position effect is due to strong genetic inactivation and supercondensation caused by specific proteins in early development. The primary DNA structure is not likely to play a key role in this process.

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Year:  1989        PMID： 2515045     DOI： 10.1007/bf00292391

Source DB:  PubMed          Journal:  Chromosoma        ISSN： 0009-5915            Impact factor:   4.316


  23 in total

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Journal:  Chromosoma       Date:  1979-03-12       Impact factor: 4.316

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Journal:  J Mol Biol       Date:  1983-02-15       Impact factor: 5.469

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Authors:  G Reuter; W Werner; H J Hoffmann
Journal:  Chromosoma       Date:  1982       Impact factor: 4.316

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Authors:  I F Zhimulev
Journal:  Chromosoma       Date:  1974-05-21       Impact factor: 4.316

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Journal:  Chromosoma       Date:  1972       Impact factor: 4.316

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Journal:  Genet Res       Date:  1967-10       Impact factor: 1.588

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Journal:  Chromosoma       Date:  1976-08-04       Impact factor: 4.316
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  9 in total

1.  Cytogenetic and molecular aspects of position effect variegation in Drosophila melanogaster. IV. Underreplication of chromosomal material as a result of gene inactivation.

Authors:  G H Umbetova; E S Belyaeva; E M Baricheva; I F Zhimulev
Journal:  Chromosoma       Date:  1991-10       Impact factor: 4.316

2.  Cytogenetic and molecular aspects of position effect variegation in Drosophila. III. Continuous and discontinuous compaction of chromosomal material as a result of position effect variegation.

Authors:  E S Belyaeva; I F Zhimulev
Journal:  Chromosoma       Date:  1991-08       Impact factor: 4.316

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Authors:  I F Zhimulev; E S Belyaeva
Journal:  Genetica       Date:  1991       Impact factor: 1.082

4.  General characteristics of the polytene chromosome from ovarian pseudonurse cells of the Drosophila melanogaster otu11 and fs(2)B mutants.

Authors:  N I Mal'ceva; H Gyurkovics; I F Zhimulev
Journal:  Chromosome Res       Date:  1995-05       Impact factor: 5.239

5.  Cytogenetic and molecular aspects of position-effect variegation in Drosophila melanogaster. V. Heterochromatin-associated protein HP1 appears in euchromatic chromosomal regions that are inactivated as a result of position-effect variegation.

Authors:  E S Belyaeva; O V Demakova; G H Umbetova; I F Zhimulev
Journal:  Chromosoma       Date:  1993-09       Impact factor: 4.316

6.  Observations on the induction of position effect variegation of euchromatic genes in Drosophila melanogaster.

Authors:  G V Pokholkova; I V Makunin; E S Belyaeva; I F Zhimulev
Journal:  Genetics       Date:  1993-05       Impact factor: 4.562

7.  Translocation breakpoints in three patients with campomelic dysplasia and autosomal sex reversal map more than 130 kb from SOX9.

Authors:  J Wirth; T Wagner; J Meyer; R A Pfeiffer; H U Tietze; W Schempp; G Scherer
Journal:  Hum Genet       Date:  1996-02       Impact factor: 4.132

8.  Su(UR)ES: a gene suppressing DNA underreplication in intercalary and pericentric heterochromatin of Drosophila melanogaster polytene chromosomes.

Authors:  E S Belyaeva; I F Zhimulev; E I Volkova; A A Alekseyenko; Y M Moshkin; D E Koryakov
Journal:  Proc Natl Acad Sci U S A       Date:  1998-06-23       Impact factor: 11.205

9.  A functionally conserved Polycomb response element from mouse HoxD complex responds to heterochromatin factors.

Authors:  Dasari Vasanthi; A Nagabhushan; Navneet Kaur Matharu; Rakesh K Mishra
Journal:  Sci Rep       Date:  2013-10-22       Impact factor: 4.379
  9 in total

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