Ewa A Ogłodek1, Anna Szota2, Marek J Just3, Danuta Moś4, Aleksander Araszkiewicz2. 1. Department of Psychiatry, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland. Electronic address: e.oglodek@wp.pl. 2. Department of Psychiatry, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland. 3. Piekary Medical Centre, Department of General Surgery, Municipal Hospital in Piekary Śląskie, Piekary Śląskie, Poland. 4. Health Care Centre Euro-Med Bytom, Bytom, Poland.
Abstract
BACKGROUND: Depression can be perceived as a psychoneuroimmunological disorder in which cytokines affecting the body's neurochemical and neuroendocrine functions play an important role. Among cytokines, chemokines participating in activation of the inflammatory response are considered to be crucial. METHODS: 160 men and women were enrolled in the study. 120 of them were diagnosed with various types of depression. The mean age was 45.2 ± 4.5 years (range: 19-47 years). The control group consisted of 40 healthy individuals. The average age in this group was 42.4 ± 4.1 years. Plasma levels of chemokines and their receptors (CCL-5 - RANTES and CXCR-5, SDF-1 and CXCR-4), as well as of IL-6, were assessed by ELISA. RESULTS: There was an increase in SDF-1 and CCL-5 levels in women and men with different severities of depression, versus the control group. Also, an increase in the IL-6 levels, CXCR4 and CCR-5 receptors was observed in both women and men with all types of depression. Levels of SDF-1 and CCL-5 chemokines, as well as of CCR-5 and CXCR4 chemokine receptors, were higher in women than in men. CONCLUSIONS: The results of this study indicate the need for assessment of CCL-5 and SDF-1 chemokines levels, as they are likely markers of developing depression. Early measurement of these chemokines levels may be helpful in choosing the best pharmacotherapy.
BACKGROUND:Depression can be perceived as a psychoneuroimmunological disorder in which cytokines affecting the body's neurochemical and neuroendocrine functions play an important role. Among cytokines, chemokines participating in activation of the inflammatory response are considered to be crucial. METHODS: 160 men and women were enrolled in the study. 120 of them were diagnosed with various types of depression. The mean age was 45.2 ± 4.5 years (range: 19-47 years). The control group consisted of 40 healthy individuals. The average age in this group was 42.4 ± 4.1 years. Plasma levels of chemokines and their receptors (CCL-5 - RANTES and CXCR-5, SDF-1 and CXCR-4), as well as of IL-6, were assessed by ELISA. RESULTS: There was an increase in SDF-1 and CCL-5 levels in women and men with different severities of depression, versus the control group. Also, an increase in the IL-6 levels, CXCR4 and CCR-5 receptors was observed in both women and men with all types of depression. Levels of SDF-1 and CCL-5 chemokines, as well as of CCR-5 and CXCR4 chemokine receptors, were higher in women than in men. CONCLUSIONS: The results of this study indicate the need for assessment of CCL-5 and SDF-1 chemokines levels, as they are likely markers of developing depression. Early measurement of these chemokines levels may be helpful in choosing the best pharmacotherapy.
Authors: Elżbieta Małujło-Balcerska; Anna Kumor-Kisielewska; Janusz Szemraj; Tadeusz Pietras Journal: Pharmacol Rep Date: 2022-03-16 Impact factor: 3.919
Authors: Olivia Bauer; Vladimir M Milenkovic; Sven Hilbert; Nina Sarubin; Johannes Weigl; Lisa-Marie Bahr; Thomas C Wetter; Barbara Heckel; Christian H Wetzel; Rainer Rupprecht; Caroline Nothdurfter Journal: Neuroimmunomodulation Date: 2021-01-27 Impact factor: 2.492
Authors: Nuria García-Marchena; Pedro Fernando Araos; Vicente Barrios; Laura Sánchez-Marín; Julie A Chowen; María Pedraz; Estela Castilla-Ortega; Pablo Romero-Sanchiz; Guillermo Ponce; Ana L Gavito; Juan Decara; Daniel Silva; Marta Torrens; Jesús Argente; Gabriel Rubio; Antonia Serrano; Fernando Rodríguez de Fonseca; Francisco Javier Pavón Journal: Front Psychiatry Date: 2017-01-18 Impact factor: 4.157