Literature DB >> 25149597

Expanding the scope of drug repurposing in pediatrics: the Children's Pharmacy Collaborative.

Julie Blatt1, Sherif Farag2, Seth J Corey3, Zafeira Sarrimanolis2, Eugene Muratov2, Denis Fourches2, Alexander Tropsha2, William P Janzen4.   

Abstract

Drug repurposing is the use of 'old' drugs for new indications, avoiding the need for time- and cost-intensive toxicity studies. This approach should be particularly attractive for pediatrics, but its use in this population has been limited. One obstacle has been the lack of a comprehensive database of drugs for which there already is at least one indication in children. We describe the development of The Children's Pharmacy Collaborative, which should grow over time, serve as a resource for professionals and families, and stimulate drug-repurposing efforts for a range of pediatric disorders.
Copyright © 2014 Elsevier Ltd. All rights reserved.

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Year:  2014        PMID: 25149597      PMCID: PMC4578872          DOI: 10.1016/j.drudis.2014.08.003

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN: 1359-6446            Impact factor:   7.851


  8 in total

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Authors:  Michael N Needle
Journal:  Pediatr Blood Cancer       Date:  2012-02-29       Impact factor: 3.167

Review 2.  How to improve R&D productivity: the pharmaceutical industry's grand challenge.

Authors:  Steven M Paul; Daniel S Mytelka; Christopher T Dunwiddie; Charles C Persinger; Bernard H Munos; Stacy R Lindborg; Aaron L Schacht
Journal:  Nat Rev Drug Discov       Date:  2010-02-19       Impact factor: 84.694

Review 3.  Obtaining and screening compound collections: a user's guide and a call to chemists.

Authors:  Paul J Hergenrother
Journal:  Curr Opin Chem Biol       Date:  2006-05-03       Impact factor: 8.822

4.  New uses for old drugs.

Authors:  Curtis R Chong; David J Sullivan
Journal:  Nature       Date:  2007-08-09       Impact factor: 49.962

5.  Propranolol for severe hemangiomas of infancy.

Authors:  Christine Léauté-Labrèze; Eric Dumas de la Roque; Thomas Hubiche; Franck Boralevi; Jean-Benoît Thambo; Alain Taïeb
Journal:  N Engl J Med       Date:  2008-06-12       Impact factor: 91.245

6.  Drug Repurposing from an Academic Perspective.

Authors:  Tudor I Oprea; Julie E Bauman; Cristian G Bologa; Tione Buranda; Alexandre Chigaev; Bruce S Edwards; Jonathan W Jarvik; Hattie D Gresham; Mark K Haynes; Brian Hjelle; Robert Hromas; Laurie Hudson; Debra A Mackenzie; Carolyn Y Muller; John C Reed; Peter C Simons; Yelena Smagley; Juan Strouse; Zurab Surviladze; Todd Thompson; Oleg Ursu; Anna Waller; Angela Wandinger-Ness; Stuart S Winter; Yang Wu; Susan M Young; Richard S Larson; Cheryl Willman; Larry A Sklar
Journal:  Drug Discov Today Ther Strateg       Date:  2011

Review 7.  Drug repurposing in pediatrics and pediatric hematology oncology.

Authors:  Julie Blatt; Seth J Corey
Journal:  Drug Discov Today       Date:  2012-07-23       Impact factor: 7.851

8.  Trust, but verify: on the importance of chemical structure curation in cheminformatics and QSAR modeling research.

Authors:  Denis Fourches; Eugene Muratov; Alexander Tropsha
Journal:  J Chem Inf Model       Date:  2010-07-26       Impact factor: 4.956

  8 in total
  11 in total

1.  The Rescue and Repurposing of Pharmaceuticals: Augmenting the Drug Development Paradigm.

Authors:  Michael D Reed
Journal:  J Pediatr Pharmacol Ther       Date:  2016 Jan-Feb

2.  Chemotext: A Publicly Available Web Server for Mining Drug-Target-Disease Relationships in PubMed.

Authors:  Stephen J Capuzzi; Thomas E Thornton; Kammy Liu; Nancy Baker; Wai In Lam; Colin P O'Banion; Eugene N Muratov; Diane Pozefsky; Alexander Tropsha
Journal:  J Chem Inf Model       Date:  2018-01-19       Impact factor: 4.956

Review 3.  Trust, but Verify II: A Practical Guide to Chemogenomics Data Curation.

Authors:  Denis Fourches; Eugene Muratov; Alexander Tropsha
Journal:  J Chem Inf Model       Date:  2016-06-22       Impact factor: 4.956

4.  Collaboration for rare disease drug discovery research.

Authors:  Nadia K Litterman; Michele Rhee; David C Swinney; Sean Ekins
Journal:  F1000Res       Date:  2014-10-31

5.  FDA approved drugs as potential Ebola treatments.

Authors:  Sean Ekins; Megan Coffee
Journal:  F1000Res       Date:  2015-02-19

6.  Illustrating and homology modeling the proteins of the Zika virus.

Authors:  Sean Ekins; John Liebler; Bruno J Neves; Warren G Lewis; Megan Coffee; Rachelle Bienstock; Christopher Southan; Carolina H Andrade
Journal:  F1000Res       Date:  2016-03-03

7.  Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.

Authors:  Min Shen; Rosita Asawa; Ya-Qin Zhang; Elizabeth Cunningham; Hongmao Sun; Alexander Tropsha; William P Janzen; Eugene N Muratov; Stephen J Capuzzi; Sherif Farag; Ajit Jadhav; Julie Blatt; Anton Simeonov; Natalia J Martinez
Journal:  Oncotarget       Date:  2017-12-19

8.  Phantom PAINS: Problems with the Utility of Alerts for Pan-Assay INterference CompoundS.

Authors:  Stephen J Capuzzi; Eugene N Muratov; Alexander Tropsha
Journal:  J Chem Inf Model       Date:  2017-02-25       Impact factor: 4.956

9.  A decision process for drug discovery in retinoblastoma.

Authors:  María Belen Cancela; Santiago Zugbi; Ursula Winter; Ana Laura Martinez; Claudia Sampor; Mariana Sgroi; Jasmine H Francis; Ralph Garippa; David H Abramson; Guillermo Chantada; Paula Schaiquevich
Journal:  Invest New Drugs       Date:  2020-11-16       Impact factor: 3.850

10.  Open drug discovery for the Zika virus.

Authors:  Sean Ekins; Daniel Mietchen; Megan Coffee; Thomas P Stratton; Joel S Freundlich; Lucio Freitas-Junior; Eugene Muratov; Jair Siqueira-Neto; Antony J Williams; Carolina Andrade
Journal:  F1000Res       Date:  2016-02-09
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