OBJECTIVE: To assess survival time and adverse events related to the administration of pimobendan to cats with congestive heart failure (CHF) secondary to hypertrophic cardiomyopathy (HCM) or hypertrophic obstructive cardiomyopathy (HOCM). DESIGN: Retrospective case-control study. ANIMALS: 27 cats receiving treatment with pimobendan and 27 cats receiving treatment without pimobendan. PROCEDURES: Medical records between 2003 and 2013 were reviewed. All cats with HCM or HOCM treated with a regimen that included pimobendan (case cats) were identified. Control cats (cats with CHF treated during the same period with a regimen that did not include pimobendan) were selected by matching to case cats on the basis of age, sex, body weight, type of cardiomyopathy, and manifestation of CHF. Data collected included signalment, physical examination findings, echocardiographic data, serum biochemical values, and survival time from initial diagnosis of CHF. Kaplan-Meier survival curves were constructed and compared by means of a log rank test. RESULTS: Cats receiving pimobendan had a significant benefit in survival time. Median survival time of case cats receiving pimobendan was 626 days, whereas median survival time for control cats not receiving pimobendan was 103 days. No significant differences were detected for any other variable. CONCLUSIONS AND CLINICAL RELEVANCE: The addition of pimobendan to traditional treatment for CHF may provide a substantial clinical benefit in survival time for HCM-affected cats with CHF and possibly HOCM-affected cats with CHF.
OBJECTIVE: To assess survival time and adverse events related to the administration of pimobendan to cats with congestive heart failure (CHF) secondary to hypertrophic cardiomyopathy (HCM) or hypertrophic obstructive cardiomyopathy (HOCM). DESIGN: Retrospective case-control study. ANIMALS: 27 cats receiving treatment with pimobendan and 27 cats receiving treatment without pimobendan. PROCEDURES: Medical records between 2003 and 2013 were reviewed. All cats with HCM or HOCM treated with a regimen that included pimobendan (case cats) were identified. Control cats (cats with CHF treated during the same period with a regimen that did not include pimobendan) were selected by matching to case cats on the basis of age, sex, body weight, type of cardiomyopathy, and manifestation of CHF. Data collected included signalment, physical examination findings, echocardiographic data, serum biochemical values, and survival time from initial diagnosis of CHF. Kaplan-Meier survival curves were constructed and compared by means of a log rank test. RESULTS:Cats receiving pimobendan had a significant benefit in survival time. Median survival time of case cats receiving pimobendan was 626 days, whereas median survival time for control cats not receiving pimobendan was 103 days. No significant differences were detected for any other variable. CONCLUSIONS AND CLINICAL RELEVANCE: The addition of pimobendan to traditional treatment for CHF may provide a substantial clinical benefit in survival time for HCM-affected cats with CHF and possibly HOCM-affected cats with CHF.
Authors: Jonathan N King; Mike Martin; Valérie Chetboul; Luca Ferasin; Anne T French; Günther Strehlau; Wolfgang Seewald; Sarah G W Smith; Simon T Swift; Susan L Roberts; Andrea M Harvey; Christopher J L Little; Sarah M A Caney; Kerry E Simpson; Andrew H Sparkes; Eleanor J Mardell; Eric Bomassi; Claude Muller; John P Sauvage; Armelle Diquélou; Matthias A Schneider; Laurence J Brown; David D Clarke; Jean-Francois Rousselot Journal: J Vet Intern Med Date: 2019-09-27 Impact factor: 3.333
Authors: Karsten E Schober; John E Rush; Virginia Luis Fuentes; Tony Glaus; Nuala J Summerfield; Kathy Wright; Linda Lehmkuhl; Gerhard Wess; Margaret P Sayer; Joao Loureiro; John MacGregor; Nicole Mohren Journal: J Vet Intern Med Date: 2021-02-05 Impact factor: 3.333
Authors: Virginia Luis Fuentes; Jonathan Abbott; Valérie Chetboul; Etienne Côté; Philip R Fox; Jens Häggström; Mark D Kittleson; Karsten Schober; Joshua A Stern Journal: J Vet Intern Med Date: 2020-04-03 Impact factor: 3.333
Authors: Jessica L Ward; Efrem Z Kussin; Melissa A Tropf; Sandra P Tou; Teresa C DeFrancesco; Bruce W Keene Journal: J Vet Intern Med Date: 2020-10-07 Impact factor: 3.333
Authors: Maureen S Oldach; Yu Ueda; Eric S Ontiveros; Samantha L Fousse; Lance C Visser; Joshua A Stern Journal: BMC Vet Res Date: 2021-02-23 Impact factor: 2.741
Authors: Samantha L Kochie; Karsten E Schober; Jaylyn Rhinehart; Randolph L Winter; John D Bonagura; Annie Showers; Vedat Yildez Journal: J Vet Intern Med Date: 2020-11-26 Impact factor: 3.175