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Literature DB >> 25147608

Optimization of Rutaecarpine as ABCA1 Up-Regulator for Treating Atherosclerosis.

Yongzhen Li¹, Tingting Feng¹, Peng Liu¹, Chang Liu¹, Xiao Wang¹, Dongsheng Li¹, Ni Li¹, Minghua Chen¹, Yanni Xu¹, Shuyi Si¹.

Abstract

ATP-binding cassette transporter A1 (ABCA1) is a key transporter and receptor in promoting cholesterol efflux, and increasing the expression level of ABCA1 is antiatherogenic. In our previous study, rutaecarpine (RUT) was found to protect ApoE(-/-) mice from developing atherosclerosis through preferentially up-regulating ABCA1 expression. In the present work, a series of RUT derivatives were synthesized and examined as ABCA1 expression up-regulators. Compounds CD1, CD6, and BCD1-2 were found to possess the most potential activity as antiatherosclerotic agents among all compounds tested.

Entities: Chemical Disease Gene Species

Keywords: ABCA1; RCT; Rutaecarpine; atherosclerosis

Year: 2014 PMID： 25147608 PMCID： PMC4137366 DOI： 10.1021/ml500131a

Source DB: PubMed Journal: ACS Med Chem Lett ISSN： 1948-5875 Impact factor: 4.345

32 in total

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Authors: Yanni Xu; Qi Liu; Yang Xu; Chang Liu; Xiao Wang; Xiaobo He; Ningyu Zhu; Jikai Liu; Yexiang Wu; Yongzhen Li; Ni Li; Tingting Feng; Fangfang Lai; Murui Zhang; Bin Hong; Jian-Dong Jiang; Shuyi Si
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4. Identification of upregulators of human ATP-binding cassette transporter A1 via high-throughput screening of a synthetic and natural compound library.

Authors: Jie Gao; Yanni Xu; Yuan Yang; Yi Yang; Zhihui Zheng; Wei Jiang; Bin Hong; Xuguang Yan; Shuyi Si
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5. Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo.

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Review 7. Pharmacological effects of rutaecarpine as a cardiovascular protective agent.

Authors: Sujie Jia; Changping Hu
Journal: Molecules Date: 2010-03-15 Impact factor: 4.411

8. Identification of dehydroxytrichostatin A as a novel up-regulator of the ATP-binding cassette transporter A1 (ABCA1).

Authors: Yang Xu; Yanni Xu; Yi Bao; Bin Hong; Shuyi Si
Journal: Molecules Date: 2011-08-25 Impact factor: 4.411

9. Low-cytotoxic synthetic bromorutaecarpine exhibits anti-inflammation and activation of transient receptor potential vanilloid type 1 activities.

Authors: Chi-Ming Lee; Jiun-An Gu; Tin-Gan Rau; Che-Hsiung Yang; Wei-Chi Yang; Shih-Hao Huang; Feng-Yen Lin; Chun-Mao Lin; Sheng-Tung Huang
Journal: Biomed Res Int Date: 2013-11-28 Impact factor: 3.411

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Authors: Seung Ho Lee; Jong-Keun Son; Byeong Seon Jeong; Tae-Cheon Jeong; Hyeon Wook Chang; Eung-Seok Lee; Yurngdong Jahng
Journal: Molecules Date: 2008-02-06 Impact factor: 4.411

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Journal: Free Neuropathol Date: 2021-12-13

2. Rational Design of a New Class of Toll-Like Receptor 4 (TLR4) Tryptamine Related Agonists by Means of the Structure- and Ligand-Based Virtual Screening for Vaccine Adjuvant Discovery.

Authors: Jan Honegr; Rafael Dolezal; David Malinak; Marketa Benkova; Ondrej Soukup; Joyce S F D de Almeida; Tanos C C Franca; Kamil Kuca; Roman Prymula
Journal: Molecules Date: 2018-01-04 Impact factor: 4.411