BACKGROUND AND OBJECTIVE: Vascular cognitive impairment may have a selective neuropsychological profile. We developed a battery for assessing mild cognitive impairment (MCI) in patients with small vessel disease (SVD), its applicability, and psychometric properties. METHODS: Among those proposed by the 2006 NINDS-CSN Consensus Conference, we selected tests for which norms based on healthy Italians and equivalent scores methodology were available. Confirmatory factor analysis was applied to ascertain the fit of the theoretically assumed dimensions to empirical data and to derive each cognitive dimension compound measures. RESULTS: The entire battery was applied to 146 out of a cohort of 201 patients with MCI and SVD. Most tests showed good applicability. Fifty-five patients, who were older and cognitively more impaired, proved unable to complete the Trail Making Test part B, the Rey-Osterrieth Complex Figure, and the Stroop test, and were excluded from the analysis. Among the remaining patients, Mini-Mental State Examination proved largely normal, while Rey-Osterrieth Complex Figure, Symbol digit modalities test, and Trail Making Test part B were most frequently abnormal. Confirmatory factor analysis showed a good fit of the 4-factor theoretical model to empirical data. Praxis domain resulted in the highest percentage of abnormal performance (65%), followed by Memory and Attention/EF domains (19% and 15%), and Language (8%). CONCLUSIONS: Our battery proved to be comprehensive, robust, and applicable. Attention-executive dysfunction and impaired memory and visuo-constructional abilities, were the prominent features. The assessment of the Consensus Conference, that included Trial Making Test, looks poorly applicable to older and cognitively impaired patients.
BACKGROUND AND OBJECTIVE:Vascular cognitive impairment may have a selective neuropsychological profile. We developed a battery for assessing mild cognitive impairment (MCI) in patients with small vessel disease (SVD), its applicability, and psychometric properties. METHODS: Among those proposed by the 2006 NINDS-CSN Consensus Conference, we selected tests for which norms based on healthy Italians and equivalent scores methodology were available. Confirmatory factor analysis was applied to ascertain the fit of the theoretically assumed dimensions to empirical data and to derive each cognitive dimension compound measures. RESULTS: The entire battery was applied to 146 out of a cohort of 201 patients with MCI and SVD. Most tests showed good applicability. Fifty-five patients, who were older and cognitively more impaired, proved unable to complete the Trail Making Test part B, the Rey-Osterrieth Complex Figure, and the Stroop test, and were excluded from the analysis. Among the remaining patients, Mini-Mental State Examination proved largely normal, while Rey-Osterrieth Complex Figure, Symbol digit modalities test, and Trail Making Test part B were most frequently abnormal. Confirmatory factor analysis showed a good fit of the 4-factor theoretical model to empirical data. Praxis domain resulted in the highest percentage of abnormal performance (65%), followed by Memory and Attention/EF domains (19% and 15%), and Language (8%). CONCLUSIONS: Our battery proved to be comprehensive, robust, and applicable. Attention-executive dysfunction and impaired memory and visuo-constructional abilities, were the prominent features. The assessment of the Consensus Conference, that included Trial Making Test, looks poorly applicable to older and cognitively impairedpatients.
Authors: A Brugnolo; F De Carli; J Accardo; M Amore; L E Bosia; C Bruzzaniti; S F Cappa; L Cocito; G Colazzo; M Ferrara; L Ghio; E Magi; G L Mancardi; F Nobili; M Pardini; R Rissotto; C Serrati; N Girtler Journal: Neurol Sci Date: 2015-11-30 Impact factor: 3.307
Authors: Anders Wallin; Gustavo C Román; Margaret Esiri; Petronella Kettunen; Johan Svensson; George P Paraskevas; Elisabeth Kapaki Journal: J Alzheimers Dis Date: 2018 Impact factor: 4.472
Authors: Emilia Salvadori; Anna Poggesi; Giovanni Pracucci; Alberto Chiti; Laura Ciolli; Mirco Cosottini; Alessandra Del Bene; Nicola De Stefano; Stefano Diciotti; Ilaria Di Donato; Andrea Ginestroni; Sandro Marini; Mario Mascalchi; Serena Nannucci; Giovanni Orlandi; Marco Pasi; Francesca Pescini; Raffaella Valenti; Antonio Federico; Maria Teresa Dotti; Ubaldo Bonuccelli; Domenico Inzitari; Leonardo Pantoni Journal: Dement Geriatr Cogn Dis Extra Date: 2018-03-29