Literature DB >> 25146937

Human lysyl oxidase-like 2.

Hee-Jung Moon1, Joel Finney1, Trey Ronnebaum1, Minae Mure2.   

Abstract

Lysyl oxidase like-2 (LOXL2) belongs to the lysyl oxidase (LOX) family, which comprises Cu(2+)- and lysine tyrosylquinone (LTQ)-dependent amine oxidases. LOXL2 is proposed to function similarly to LOX in the extracellular matrix (ECM) by promoting crosslinking of collagen and elastin. LOXL2 has also been proposed to regulate extracellular and intracellular cell signaling pathways. Dysregulation of LOXL2 has been linked to many diseases, including cancer, pro-oncogenic angiogenesis, fibrosis and heart diseases. In this review, we will give an overview of the current understandings and hypotheses regarding the molecular functions of LOXL2.
Copyright © 2014 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Cell signaling; Extracellular matrix; Lysine tyrosylquinone (LTQ); Lysyl oxidase family; Lysyl oxidase like-2; Tumor metastasis/invasion

Mesh：

Substances：

Year:  2014        PMID： 25146937      PMCID： PMC6309629          DOI： 10.1016/j.bioorg.2014.07.003

Source DB:  PubMed          Journal:  Bioorg Chem        ISSN： 0045-2068            Impact factor:   5.275


  44 in total

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2.  New medical treatment strategies for nonalcoholic steatohepatitis.

Authors:  Michael Fuchs
Journal:  Curr Treat Options Gastroenterol       Date:  2015-06

3.  Lysyl Oxidase-like Protein LOXL2 Promotes Lung Metastasis of Breast Cancer.

Authors:  Fernando Salvador; Alberto Martin; Celia López-Menéndez; Gema Moreno-Bueno; Vanesa Santos; Alberto Vázquez-Naharro; Patricia G Santamaria; Saleta Morales; Pierre R Dubus; Laura Muinelo-Romay; Rafael López-López; Jason C Tung; Valerie M Weaver; Francisco Portillo; Amparo Cano
Journal:  Cancer Res       Date:  2017-07-18       Impact factor: 12.701

4.  Proteolytic processing of lysyl oxidase-like-2 in the extracellular matrix is required for crosslinking of basement membrane collagen IV.

Authors:  Alberto J López-Jiménez; Trayambak Basak; Roberto M Vanacore
Journal:  J Biol Chem       Date:  2017-09-01       Impact factor: 5.157

5.  Small Molecule Lysyl Oxidase-like 2 (LOXL2) Inhibitors: The Identification of an Inhibitor Selective for LOXL2 over LOX.

Authors:  John H Hutchinson; Martin W Rowbottom; David Lonergan; Janice Darlington; Pat Prodanovich; Christopher D King; Jilly F Evans; Gretchen Bain
Journal:  ACS Med Chem Lett       Date:  2017-03-01       Impact factor: 4.345

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Authors:  M Noureddin; Q M Anstee; R Loomba
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Review 7.  Promising therapies for treatment of nonalcoholic steatohepatitis.

Authors:  Mazen Noureddin; Alice Zhang; Rohit Loomba
Journal:  Expert Opin Emerg Drugs       Date:  2016-08-28       Impact factor: 4.191

Review 8.  Non-alcoholic steatohepatitis: emerging molecular targets and therapeutic strategies.

Authors:  Giovanni Musso; Maurizio Cassader; Roberto Gambino
Journal:  Nat Rev Drug Discov       Date:  2016-01-22       Impact factor: 84.694

9.  The serum level and significance of lysyl oxidase-like 2 in patients with rheumatoid arthritis-associated interstitial lung disease.

Authors:  Qiang Fu; Yu Bai; Yuan Liu; Junfei Zhou; Yi Zheng
Journal:  Clin Rheumatol       Date:  2017-10-19       Impact factor: 2.980

10.  Elastin is heterogeneously cross-linked.

Authors:  Christoph U Schräder; Andrea Heinz; Petra Majovsky; Berin Karaman Mayack; Jürgen Brinckmann; Wolfgang Sippl; Christian E H Schmelzer
Journal:  J Biol Chem       Date:  2018-08-14       Impact factor: 5.157
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