Literature DB >> 25146731

Amyloid-β precursor protein synthesis inhibitors for Alzheimer's disease treatment.

Nigel H Greig1, Kumar Sambamurti, Debomoy K Lahiri, Robert E Becker.   

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Year:  2014        PMID： 25146731      PMCID： PMC5179032          DOI： 10.1002/ana.24254

Source DB:  PubMed          Journal:  Ann Neurol        ISSN： 0364-5134            Impact factor:   10.422


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  7 in total

1.  Modulation of amyloid precursor protein expression reduces β-amyloid deposition in a mouse model.

Authors:  Ayodeji A Asuni; Maitea Guridi; Joanna E Pankiewicz; Sandrine Sanchez; Martin J Sadowski
Journal:  Ann Neurol       Date:  2014-04-28       Impact factor: 10.422

2.  Fire in the ashes: can failed Alzheimer's disease drugs succeed with second chances?

Authors:  Robert E Becker; Nigel H Greig
Journal:  Alzheimers Dement       Date:  2012-03-30       Impact factor: 21.566

3.  The experimental Alzheimer's disease drug posiphen [(+)-phenserine] lowers amyloid-beta peptide levels in cell culture and mice.

Authors:  Debomoy K Lahiri; DeMao Chen; Bryan Maloney; Harold W Holloway; Qian-sheng Yu; Tada Utsuki; Tony Giordano; Kumar Sambamurti; Nigel H Greig
Journal:  J Pharmacol Exp Ther       Date:  2006-09-26       Impact factor: 4.030

4.  A new roadmap for drug development for Alzheimer's disease.

Authors:  Robert E Becker; Nigel H Greig; Ezio Giacobini; Lon S Schneider; Luigi Ferrucci
Journal:  Nat Rev Drug Discov       Date:  2013-12-20       Impact factor: 84.694

Review 5.  A new regulatory road-map for Alzheimer's disease drug development.

Authors:  Robert E Becker; Nigel H Greig
Journal:  Curr Alzheimer Res       Date:  2014-03       Impact factor: 3.498

6.  The anticholinesterase phenserine and its enantiomer posiphen as 5'untranslated-region-directed translation blockers of the Parkinson's alpha synuclein expression.

Authors:  Sohan Mikkilineni; Ippolita Cantuti-Castelvetri; Catherine M Cahill; Amelie Balliedier; Nigel H Greig; Jack T Rogers
Journal:  Parkinsons Dis       Date:  2012-05-29

7.  Posiphen as a candidate drug to lower CSF amyloid precursor protein, amyloid-β peptide and τ levels: target engagement, tolerability and pharmacokinetics in humans.

Authors:  Maria L Maccecchini; Mee Young Chang; Catherine Pan; Varghese John; Henrik Zetterberg; Nigel H Greig
Journal:  J Neurol Neurosurg Psychiatry       Date:  2012-07-11       Impact factor: 10.154
  7 in total
  3 in total

1.  (-)-Phenserine Ameliorates Contusion Volume, Neuroinflammation, and Behavioral Impairments Induced by Traumatic Brain Injury in Mice.

Authors:  Shih-Chang Hsueh; Daniela Lecca; Nigel H Greig; Jia-Yi Wang; Warren Selman; Barry J Hoffer; Jonathan P Miller; Yung-Hsiao Chiang
Journal:  Cell Transplant       Date:  2019-06-10       Impact factor: 4.064

2.  Novel upregulation of amyloid-β precursor protein (APP) by microRNA-346 via targeting of APP mRNA 5'-untranslated region: Implications in Alzheimer's disease.

Authors:  Justin M Long; Bryan Maloney; Jack T Rogers; Debomoy K Lahiri
Journal:  Mol Psychiatry       Date:  2018-11-23       Impact factor: 15.992

Review 3.  Repositioning drugs for traumatic brain injury - N-acetyl cysteine and Phenserine.

Authors:  Barry J Hoffer; Chaim G Pick; Michael E Hoffer; Robert E Becker; Yung-Hsiao Chiang; Nigel H Greig
Journal:  J Biomed Sci       Date:  2017-09-09       Impact factor: 8.410
  3 in total

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