| Literature DB >> 25146376 |
Gerard E Holder1, Christopher M McGary, Edward M Johnson, Rubo Zheng, Vijay T John, Chie Sugimoto, Marcelo J Kuroda, Woong-Ki Kim.
Abstract
We examined the expression of the mannose receptor CD206 by perivascular macrophages (PVM) in normal human and monkey brains and in brains of HIV-infected humans and of monkeys infected with simian immunodeficiency virus (SIV). Depletion of brain PVM in SIV-infected monkeys by intrathecal injection of liposome-encapsulated bisphosphonates eliminated CD206-expressing cells in the brain, confirming their perivascular location and phagocytic capacity. In vivo labeling with bromodeoxyuridine in normal uninfected and SIV-infected macaques in combination with CD206 immunostaining revealed a CD206+-to-CD206- shift within pre-existing PVM during SIV brain infection and neuroinflammation. These findings identify CD206 as a unique marker of human and macaque PVM, and underscore the utility of this marker in studying the origin, turnover and functions of these cells in AIDS.Entities:
Mesh：
Substances：
Year: 2014 PMID： 25146376 PMCID： PMC4364002 DOI： 10.1007/s11481-014-9564-y
Source DB: PubMed Journal: J Neuroimmune Pharmacol ISSN： 1557-1890 Impact factor: 4.147