Literature DB >> 25145482

The impact of the endoplasmic reticulum protein-folding environment on cancer development.

Miao Wang1, Randal J Kaufman1.   

Abstract

The endoplasmic reticulum (ER) is an essential organelle in eukaryotic cells for the storage and regulated release of calcium and as the entrance to the secretory pathway. Protein misfolding in the ER causes accumulation of misfolded proteins (ER stress) and activation of the unfolded protein response (UPR), which has evolved to maintain a productive ER protein-folding environment. Both ER stress and UPR activation are documented in many different human cancers. In this Review, we summarize the impact of ER stress and UPR activation on every aspect of cancer and discuss outstanding questions for which answers will pave the way for therapeutics.

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Year:  2014        PMID： 25145482     DOI： 10.1038/nrc3800

Source DB:  PubMed          Journal:  Nat Rev Cancer        ISSN： 1474-175X            Impact factor:   60.716


  198 in total

1.  Endoplasmic reticulum stress accelerates p53 degradation by the cooperative actions of Hdm2 and glycogen synthase kinase 3beta.

Authors:  Olivier Pluquet; Li-Ke Qu; Dionissios Baltzis; Antonis E Koromilas
Journal:  Mol Cell Biol       Date:  2005-11       Impact factor: 4.272

2.  ER stress triggers apoptosis by activating BH3-only protein Bim.

Authors:  Hamsa Puthalakath; Lorraine A O'Reilly; Priscilla Gunn; Lily Lee; Priscilla N Kelly; Nicholas D Huntington; Peter D Hughes; Ewa M Michalak; Jennifer McKimm-Breschkin; Noburo Motoyama; Tomomi Gotoh; Shizuo Akira; Philippe Bouillet; Andreas Strasser
Journal:  Cell       Date:  2007-06-29       Impact factor: 41.582

3.  Coupling of endoplasmic reticulum stress to CDDO-Me-induced up-regulation of death receptor 5 via a CHOP-dependent mechanism involving JNK activation.

Authors:  Wei Zou; Ping Yue; Fadlo R Khuri; Shi-Yong Sun
Journal:  Cancer Res       Date:  2008-09-15       Impact factor: 12.701

4.  The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response.

Authors:  W Tirasophon; K Lee; B Callaghan; A Welihinda; R J Kaufman
Journal:  Genes Dev       Date:  2000-11-01       Impact factor: 11.361

5.  Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes.

Authors:  Umut Ozcan; Qiong Cao; Erkan Yilmaz; Ann-Hwee Lee; Neal N Iwakoshi; Esra Ozdelen; Gürol Tuncman; Cem Görgün; Laurie H Glimcher; Gökhan S Hotamisligil
Journal:  Science       Date:  2004-10-15       Impact factor: 47.728

6.  Physiological stresses inhibit guanine-nucleotide-exchange factor in Ehrlich cells.

Authors:  A G Rowlands; K S Montine; E C Henshaw; R Panniers
Journal:  Eur J Biochem       Date:  1988-07-15

7.  Glucose-regulated protein 78 as a novel effector of BRCA1 for inhibiting stress-induced apoptosis.

Authors:  B H Y Yeung; B W Y Kwan; Q Y He; A S Lee; J Liu; A S T Wong
Journal:  Oncogene       Date:  2008-09-08       Impact factor: 9.867

8.  ER stress activates the NLRP3 inflammasome via an UPR-independent pathway.

Authors:  P Menu; A Mayor; R Zhou; A Tardivel; H Ichijo; K Mori; J Tschopp
Journal:  Cell Death Dis       Date:  2012-01-26       Impact factor: 8.469

9.  Evidence for eIF2α phosphorylation-independent effects of GSK2656157, a novel catalytic inhibitor of PERK with clinical implications.

Authors:  Jothilatha Krishnamoorthy; Kamindla Rajesh; Farzaneh Mirzajani; Polixenia Kesoglidou; Andreas I Papadakis; Antonis E Koromilas
Journal:  Cell Cycle       Date:  2014-01-08       Impact factor: 4.534

10.  ER stress affects processing of MHC class I-associated peptides.

Authors:  Diana P Granados; Pierre-Luc Tanguay; Marie-Pierre Hardy; Etienne Caron; Danielle de Verteuil; Sylvain Meloche; Claude Perreault
Journal:  BMC Immunol       Date:  2009-02-16       Impact factor: 3.615
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  381 in total

Review 1.  Evolving Lessons on the Complex Role of AMPK in Normal Physiology and Cancer.

Authors:  Biplab Dasgupta; Rishi Raj Chhipa
Journal:  Trends Pharmacol Sci       Date:  2015-12-20       Impact factor: 14.819

Review 2.  Protein misfolding in the endoplasmic reticulum as a conduit to human disease.

Authors:  Miao Wang; Randal J Kaufman
Journal:  Nature       Date:  2016-01-21       Impact factor: 49.962

Review 3.  Gene Therapy Strategies to Restore ER Proteostasis in Disease.

Authors:  Vicente Valenzuela; Kasey L Jackson; Sergio P Sardi; Claudio Hetz
Journal:  Mol Ther       Date:  2018-04-07       Impact factor: 11.454

4.  Decreased contraction induced by endothelium-derived contracting factor in prolonged treatment of rat renal artery with endoplasmic reticulum stress inducer.

Authors:  Makoto Ando; Takayuki Matsumoto; Kumiko Taguchi; Tsuneo Kobayashi
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2018-05-04       Impact factor: 3.000

5.  Development of a stress response therapy targeting aggressive prostate cancer.

Authors:  Hao G Nguyen; Crystal S Conn; Yae Kye; Lingru Xue; Craig M Forester; Janet E Cowan; Andrew C Hsieh; John T Cunningham; Charles Truillet; Feven Tameire; Michael J Evans; Christopher P Evans; Joy C Yang; Byron Hann; Constantinos Koumenis; Peter Walter; Peter R Carroll; Davide Ruggero
Journal:  Sci Transl Med       Date:  2018-05-02       Impact factor: 17.956

Review 6.  Snapshot: implications for melatonin in endoplasmic reticulum homeostasis.

Authors:  Wei Hu; Zhiqiang Ma; Shouyin Di; Shuai Jiang; Yue Li; Chongxi Fan; Yang Yang; Dongjin Wang
Journal:  Br J Pharmacol       Date:  2016-11-16       Impact factor: 8.739

Review 7.  Beyond Alkylating Agents for Gliomas: Quo Vadimus?

Authors:  Vinay K Puduvalli; Rekha Chaudhary; Samuel G McClugage; James Markert
Journal:  Am Soc Clin Oncol Educ Book       Date:  2017

8.  Chaperone-Mediated Autophagy Promotes Beclin1 Degradation in Persistently Infected Hepatitis C Virus Cell Culture.

Authors:  Yucel Aydin; Christopher M Stephens; Srinivas Chava; Zahra Heidari; Rajesh Panigrahi; Donkita D Williams; Kylar Wiltz; Antoinette Bell; Wallace Wilson; Krzysztof Reiss; Srikanta Dash
Journal:  Am J Pathol       Date:  2018-08-01       Impact factor: 4.307

9.  eIF2α phosphorylation controls thermal nociception.

Authors:  Arkady Khoutorsky; Robert E Sorge; Masha Prager-Khoutorsky; Sophie Anne Pawlowski; Geraldine Longo; Seyed Mehdi Jafarnejad; Soroush Tahmasebi; Loren J Martin; Mark H Pitcher; Christos G Gkogkas; Reza Sharif-Naeini; Alfredo Ribeiro-da-Silva; Charles W Bourque; Fernando Cervero; Jeffrey S Mogil; Nahum Sonenberg
Journal:  Proc Natl Acad Sci U S A       Date:  2016-10-03       Impact factor: 11.205

10.  Geldanamycin-Derived HSP90 Inhibitors Are Synthetic Lethal with NRF2.

Authors:  Liam Baird; Takafumi Suzuki; Yushi Takahashi; Eiji Hishinuma; Daisuke Saigusa; Masayuki Yamamoto
Journal:  Mol Cell Biol       Date:  2020-10-26       Impact factor: 4.272
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