Literature DB >> 25145437

Lysyl oxidase in cancer research.

Lara Perryman1, Janine T Erler.   

Abstract

Metastasis is the main reason for cancer-associated deaths and therapies are desperately needed to target the progression of cancer. Lysyl oxidase (LOX) plays a pivotal role in cancer progression, including metastasis, and is therefore is an attractive therapeutic target. In this review we will breakdown the process of cancer progression and the various roles that LOX plays has in the advancement of cancer. We will highlight why LOX is an exciting therapeutic target for the future.

Entities:  

Keywords:  angiogenesis; cancer; extracellular matrix; lysyl oxidase; metastasis; premetastatic niche; prognostic markers; stroma; therapeutic targets

Mesh：

Substances：

Year:  2014        PMID： 25145437     DOI： 10.2217/fon.14.39

Source DB:  PubMed          Journal:  Future Oncol        ISSN： 1479-6694            Impact factor:   3.404


  19 in total

Review 1.  Emerging enzymatic targets controlling angiogenesis in cancer: preclinical evidence and potential clinical applications.

Authors:  Biagio Ricciuti; Jennifer Foglietta; Rita Chiari; Amirhossein Sahebkar; Maciej Banach; Vanessa Bianconi; Matteo Pirro
Journal:  Med Oncol       Date:  2017-12-04       Impact factor: 3.064

2.  Cancer-Associated Fibroblasts Induce a Collagen Cross-link Switch in Tumor Stroma.

Authors:  Daniela Pankova; Yulong Chen; Masahiko Terajima; Mark J Schliekelman; Brandi N Baird; Monica Fahrenholtz; Li Sun; Bartley J Gill; Tegy J Vadakkan; Min P Kim; Young-Ho Ahn; Jonathon D Roybal; Xin Liu; Edwin Roger Parra Cuentas; Jaime Rodriguez; Ignacio I Wistuba; Chad J Creighton; Don L Gibbons; John M Hicks; Mary E Dickinson; Jennifer L West; K Jane Grande-Allen; Samir M Hanash; Mitsuo Yamauchi; Jonathan M Kurie
Journal:  Mol Cancer Res       Date:  2015-12-02       Impact factor: 5.852

3.  Imaging and targeting LOX-mediated tissue remodeling with a reactive collagen peptide.

Authors:  Matthew R Aronoff; Paul Hiebert; Nina B Hentzen; Sabine Werner; Helma Wennemers
Journal:  Nat Chem Biol       Date:  2021-07-12       Impact factor: 15.040

Review 4.  Lysyl Oxidase and the Tumor Microenvironment.

Authors:  Tong-Hong Wang; Shih-Min Hsia; Tzong-Ming Shieh
Journal:  Int J Mol Sci       Date:  2016-12-29       Impact factor: 5.923

Review 5.  Cancer Associated Fibroblasts: The Architects of Stroma Remodeling.

Authors:  Alice Santi; Fernanda G Kugeratski; Sara Zanivan
Journal:  Proteomics       Date:  2018-02-01       Impact factor: 3.984

6.  Tumor macrophages are pivotal constructors of tumor collagenous matrix.

Authors:  Ran Afik; Ehud Zigmond; Milena Vugman; Mordehay Klepfish; Elee Shimshoni; Metsada Pasmanik-Chor; Anjana Shenoy; Elad Bassat; Zamir Halpern; Tamar Geiger; Irit Sagi; Chen Varol
Journal:  J Exp Med       Date:  2016-10-03       Impact factor: 14.307

7.  Cooperative Effect of miR-141-3p and miR-145-5p in the Regulation of Targets in Clear Cell Renal Cell Carcinoma.

Authors:  Julia Liep; Ergin Kilic; Hellmuth A Meyer; Jonas Busch; Klaus Jung; Anja Rabien
Journal:  PLoS One       Date:  2016-06-23       Impact factor: 3.240

8.  Lysyl oxidase is involved in synovial hyperplasia and angiogenesis in rats with collagen‑induced arthritis.

Authors:  Fan Wang; Juan Wan; Qiuyan Li; Mingzhu Zhang; Qiaofeng Wan; Chen Ji; Haibo Li; Rongqing Liu; Mei Han
Journal:  Mol Med Rep       Date:  2017-09-07       Impact factor: 2.952

9.  Lysyl oxidase inhibition via β-aminoproprionitrile hampers human umbilical vein endothelial cell angiogenesis and migration in vitro.

Authors:  Lin Shi; Ning Zhang; Hetao Liu; Lei Zhao; Jing Liu; Juan Wan; Wenyi Wu; Hetian Lei; Rongqing Liu; Mei Han
Journal:  Mol Med Rep       Date:  2018-01-26       Impact factor: 2.952

Review 10.  Hyaluronan, Cancer-Associated Fibroblasts and the Tumor Microenvironment in Malignant Progression.

Authors:  James B McCarthy; Dorraya El-Ashry; Eva A Turley
Journal:  Front Cell Dev Biol       Date:  2018-05-08
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