Hongxia Wang1, Pingshuan Dong. 1. Department of Cardiology, First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China.
Abstract
BACKGROUND: Thrombomodulin (TM) -33G/A and Ala455Val polymorphisms have been indicated to be correlated with the risk of coronary artery disease (CAD), but study results are still inclusive. Thus, a meta-analysis was carried out. MATERIALS AND METHODS: Databases including PubMed, Embase, CNKI, and Web of Science (ISI) were searched. Data were extracted and pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. RESULTS: Thirteen case-control studies on the relationship between TM -33G/A and Ala455Val polymorphisms and the risk of CAD were included in this meta-analysis. The association between the TM -33G/A polymorphism and the risk of CAD was significant (OR=1.65; 95% CI, 1.35-2.02; P<0.01; I(2)=15%). This result remained statistically significant when the adjusted ORs were combined (OR=1.50; 95% CI, 1.23-1.84; P<0.01; I(2)=0%). The association between the TM Ala455Val polymorphism and the risk of CAD was also significant (OR=1.14; 95% CI, 1.05-1.24; P<0.01; I(2)=0%). This result remained statistically significant when the adjusted ORs were combined (OR=1.57; 95% CI, 1.05-2.34; P=0.03; I(2)=32%). CONCLUSION: This meta-analysis suggested that TM -33G/A and Ala455Val polymorphisms were risk factors for CAD.
BACKGROUND:Thrombomodulin (TM) -33G/A and Ala455Val polymorphisms have been indicated to be correlated with the risk of coronary artery disease (CAD), but study results are still inclusive. Thus, a meta-analysis was carried out. MATERIALS AND METHODS: Databases including PubMed, Embase, CNKI, and Web of Science (ISI) were searched. Data were extracted and pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. RESULTS: Thirteen case-control studies on the relationship between TM-33G/A and Ala455Val polymorphisms and the risk of CAD were included in this meta-analysis. The association between the TM-33G/A polymorphism and the risk of CAD was significant (OR=1.65; 95% CI, 1.35-2.02; P<0.01; I(2)=15%). This result remained statistically significant when the adjusted ORs were combined (OR=1.50; 95% CI, 1.23-1.84; P<0.01; I(2)=0%). The association between the TM Ala455Val polymorphism and the risk of CAD was also significant (OR=1.14; 95% CI, 1.05-1.24; P<0.01; I(2)=0%). This result remained statistically significant when the adjusted ORs were combined (OR=1.57; 95% CI, 1.05-2.34; P=0.03; I(2)=32%). CONCLUSION: This meta-analysis suggested that TM-33G/A and Ala455Val polymorphisms were risk factors for CAD.
Authors: C Peghaire; N P Dufton; M Lang; I I Salles-Crawley; J Ahnström; V Kalna; C Raimondi; C Pericleous; L Inuabasi; R Kiseleva; V R Muzykantov; J C Mason; G M Birdsey; A M Randi Journal: Nat Commun Date: 2019-11-01 Impact factor: 14.919