BACKGROUND: This study investigated whether teneligliptin, a novel dipeptidyl peptidase-4 inhibitor, ameliorated glucose fluctuations in hospitalized Japanese patients with type 2 diabetes receiving insulin therapy, with or without other antidiabetes drugs, and using continuous glucose monitoring (CGM). PATIENTS AND METHODS: Twenty-six patients with type 2 diabetes were admitted for glycemic control. After admission, patients continued to be treated with optimal dietary therapy plus insulin therapy, with or without other antidiabetes drugs, until they achieved stable glycemic control. CGM measurements were made for 7 consecutive days. On Days 1-3, patients received insulin with or without other antidiabetes drugs, and on Days 4-7, teneligliptin 20 mg once daily at breakfast was added to ongoing therapy. Doses of insulin were fixed during the study. Levels of serum glycated albumin (GA), 1,5-anhydro-d-glucitol (1,5-AG), and high-sensitivity C-reactive protein (hsCRP) were measured. RESULTS: Add-on treatment with teneligliptin led to significant improvements in 24-h mean glucose levels, the proportion of time in normoglycemia, mean amplitude of glycemic excursions, and total area under the curve within 2 h after each meal. The proportion of time in hypoglycemia and hsCRP levels did not increase significantly compared with before teneligliptin. Values of 1,5-AG and GA were significantly improved by treatment with teneligliptin. CONCLUSIONS: Addition of teneligliptin to insulin therapy led to a significant improvement in diurnal glycemic control and significant reductions in glucose fluctuations in 24-h periods without increasing hypoglycemia in Japanese patients with type 2 diabetes on insulin therapy, with or without other antidiabetes agents.
BACKGROUND: This study investigated whether teneligliptin, a novel dipeptidyl peptidase-4 inhibitor, ameliorated glucose fluctuations in hospitalized Japanese patients with type 2 diabetes receiving insulin therapy, with or without other antidiabetes drugs, and using continuous glucose monitoring (CGM). PATIENTS AND METHODS: Twenty-six patients with type 2 diabetes were admitted for glycemic control. After admission, patients continued to be treated with optimal dietary therapy plus insulin therapy, with or without other antidiabetes drugs, until they achieved stable glycemic control. CGM measurements were made for 7 consecutive days. On Days 1-3, patients received insulin with or without other antidiabetes drugs, and on Days 4-7, teneligliptin 20 mg once daily at breakfast was added to ongoing therapy. Doses of insulin were fixed during the study. Levels of serum glycated albumin (GA), 1,5-anhydro-d-glucitol (1,5-AG), and high-sensitivity C-reactive protein (hsCRP) were measured. RESULTS: Add-on treatment with teneligliptin led to significant improvements in 24-h mean glucose levels, the proportion of time in normoglycemia, mean amplitude of glycemic excursions, and total area under the curve within 2 h after each meal. The proportion of time in hypoglycemia and hsCRP levels did not increase significantly compared with before teneligliptin. Values of 1,5-AG and GA were significantly improved by treatment with teneligliptin. CONCLUSIONS: Addition of teneligliptin to insulin therapy led to a significant improvement in diurnal glycemic control and significant reductions in glucose fluctuations in 24-h periods without increasing hypoglycemia in Japanese patients with type 2 diabetes on insulin therapy, with or without other antidiabetes agents.
Authors: Matthias Eckhardt; Elke Langkopf; Michael Mark; Moh Tadayyon; Leo Thomas; Herbert Nar; Waldemar Pfrengle; Brian Guth; Ralf Lotz; Peter Sieger; Holger Fuchs; Frank Himmelsbach Journal: J Med Chem Date: 2007-12-01 Impact factor: 7.446
Authors: T Vilsbøll; J Rosenstock; H Yki-Järvinen; W T Cefalu; Y Chen; E Luo; B Musser; P J Andryuk; Y Ling; K D Kaufman; J M Amatruda; S S Engel; L Katz Journal: Diabetes Obes Metab Date: 2010-02 Impact factor: 6.577
Authors: L Xu; C Dalla Man; B Charbonnel; G Meninger; M J Davies; D Williams-Herman; C Cobelli; P P Stein Journal: Diabetes Obes Metab Date: 2008-05-12 Impact factor: 6.577
Authors: William J Metzler; Joseph Yanchunas; Carolyn Weigelt; Kevin Kish; Herbert E Klei; Dianlin Xie; Yaqun Zhang; Martin Corbett; James K Tamura; Bin He; Lawrence G Hamann; Mark S Kirby; Jovita Marcinkeviciene Journal: Protein Sci Date: 2008-02 Impact factor: 6.725
Authors: Edwin B Villhauer; John A Brinkman; Goli B Naderi; Bryan F Burkey; Beth E Dunning; Kapa Prasad; Bonnie L Mangold; Mary E Russell; Thomas E Hughes Journal: J Med Chem Date: 2003-06-19 Impact factor: 7.446