Literature DB >> 25143583

Characterization of multiple cytomegalovirus drug resistance mutations detected in a hematopoietic stem cell transplant recipient by recombinant phenotyping.

Emilien Drouot1, Jocelyne Piret1, Marc H Lebel2, Guy Boivin3.   

Abstract

Cytomegalovirus resistance to antivirals is a major problem in transplant recipients. We evaluated the impact of five mutations (A594V, L595F, and E655K in the UL97 gene and V526L and E756K in the UL54 gene), detected in a blood sample from a stem cell transplant recipient, on drug susceptibilities and replicative capacities of recombinant viruses.
Copyright © 2014, American Society for Microbiology. All Rights Reserved.

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Year:  2014        PMID： 25143583      PMCID： PMC4313248          DOI： 10.1128/JCM.02205-14

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  18 in total

1.  Viral DNA polymerase mutations associated with drug resistance in human cytomegalovirus.

Authors:  Sunwen Chou; Nell S Lurain; Kenneth D Thompson; Richard C Miner; W Lawrence Drew
Journal:  J Infect Dis       Date:  2003-06-16       Impact factor: 5.226

2.  Emergence and compartmentalization of fatal multi-drug-resistant cytomegalovirus infection in a patient with autosomal-recessive severe combined immune deficiency.

Authors:  Samuel C Blackman; Nell S Lurain; David P Witte; Alexandra H Filipovich; Pam Groen; Mark R Schleiss
Journal:  J Pediatr Hematol Oncol       Date:  2004-09       Impact factor: 1.289

Review 3.  Complications, diagnosis, management, and prevention of CMV infections: current and future.

Authors:  Michael Boeckh
Journal:  Hematology Am Soc Hematol Educ Program       Date:  2011

4.  Cytomegalovirus UL97 phosphotransferase mutations that affect susceptibility to ganciclovir.

Authors:  Sunwen Chou; Rachel H Waldemer; Anne E Senters; Kevin S Michels; George W Kemble; Richard C Miner; W Lawrence Drew
Journal:  J Infect Dis       Date:  2001-12-17       Impact factor: 5.226

5.  En passant mutagenesis: a two step markerless red recombination system.

Authors:  B Karsten Tischer; Gregory A Smith; Nikolaus Osterrieder
Journal:  Methods Mol Biol       Date:  2010

6.  Letermovir for cytomegalovirus prophylaxis in hematopoietic-cell transplantation.

Authors:  Roy F Chemaly; Andrew J Ullmann; Susanne Stoelben; Marie Paule Richard; Martin Bornhäuser; Christoph Groth; Hermann Einsele; Margarida Silverman; Kathleen M Mullane; Janice Brown; Horst Nowak; Katrin Kölling; Hans P Stobernack; Peter Lischka; Holger Zimmermann; Helga Rübsamen-Schaeff; Richard E Champlin; Gerhard Ehninger
Journal:  N Engl J Med       Date:  2014-05-08       Impact factor: 91.245

7.  Novel method based on "en passant" mutagenesis coupled with a gaussia luciferase reporter assay for studying the combined effects of human cytomegalovirus mutations.

Authors:  Emilien Drouot; Jocelyne Piret; Guy Boivin
Journal:  J Clin Microbiol       Date:  2013-07-17       Impact factor: 5.948

8.  Fluorescence-based assay for phenotypic characterization of human cytomegalovirus polymerase mutations regarding drug susceptibility and viral replicative fitness.

Authors:  Meike Chevillotte; Axel Schubert; Thomas Mertens; Jens von Einem
Journal:  Antimicrob Agents Chemother       Date:  2009-06-22       Impact factor: 5.191

9.  Cytomegalovirus infection in pediatric allogenic hematopoietic stem cell transplantation. A single center experience.

Authors:  M Sedky; Y Mekki; V Mialou; N Bleyzac; S Girard; E Salama; H Abdel Rahman; Y Bertrand
Journal:  Pediatr Hematol Oncol       Date:  2013-12-05       Impact factor: 1.969

10.  Success and failure of artesunate treatment in five transplant recipients with disease caused by drug-resistant cytomegalovirus.

Authors:  R Germi; C Mariette; S Alain; J Lupo; A Thiebaut; J P Brion; O Epaulard; C Saint Raymond; P Malvezzi; P Morand
Journal:  Antiviral Res       Date:  2013-11-01       Impact factor: 5.970
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  9 in total

1.  Differentiated Levels of Ganciclovir Resistance Conferred by Mutations at Codons 591 to 603 of the Cytomegalovirus UL97 Kinase Gene.

Authors:  Sunwen Chou; Ronald J Ercolani; Adam L Vanarsdall
Journal:  J Clin Microbiol       Date:  2017-04-26       Impact factor: 5.948

2.  Drug Susceptibility and Replicative Capacity of Multidrug-Resistant Recombinant Human Cytomegalovirus Harboring Mutations in UL56 and UL54 Genes.

Authors:  Jocelyne Piret; Nathalie Goyette; Guy Boivin
Journal:  Antimicrob Agents Chemother       Date:  2017-10-24       Impact factor: 5.191

Review 3.  Approach to drug-resistant cytomegalovirus in transplant recipients.

Authors:  Sunwen Chou
Journal:  Curr Opin Infect Dis       Date:  2015-08       Impact factor: 4.915

4.  Antiviral Drugs Against Herpesviruses.

Authors:  Jocelyne Piret; Guy Boivin
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

5.  Antiviral-resistant cytomegalovirus infections in solid organ transplantation in the Netherlands.

Authors:  Coretta C Van Leer Buter; Danielle W K de Voogd; Hans Blokzijl; Anoek A E de Joode; Stefan P Berger; Erik A M Verschuuren; Hubert G M Niesters
Journal:  J Antimicrob Chemother       Date:  2019-08-01       Impact factor: 5.790

6.  Analysis of Novel Drug-Resistant Human Cytomegalovirus DNA Polymerase Mutations Reveals the Role of a DNA-Binding Loop in Phosphonoformic Acid Resistance.

Authors:  Kye Ryeong Park; Young-Eui Kim; Amen Shamim; Shuang Gong; Soo-Han Choi; Kyeong Kyu Kim; Yae-Jean Kim; Jin-Hyun Ahn
Journal:  Front Microbiol       Date:  2022-02-03       Impact factor: 5.640

7.  Unusual accumulation of a wide array of antimicrobial resistance mechanisms in a patient with cytomegalovirus-associated hemophagocytic lymphohistiocytosis: a case report.

Authors:  Mohammad Rubayet Hasan; Manu Somasundaram Sundaram; Sathyavathi Sundararaju; Kin-Ming Tsui; Mohammed Yousuf Karim; Diane Roscoe; Omar Imam; Mohammad A Janahi; Eva Thomas; Simon Dobson; Rusung Tan; Patrick Tang; Andres Perez Lopez
Journal:  BMC Infect Dis       Date:  2020-03-20       Impact factor: 3.090

8.  Divide et impera: An In Silico Screening Targeting HCMV ppUL44 Processivity Factor Homodimerization Identifies Small Molecules Inhibiting Viral Replication.

Authors:  Hanieh Ghassabian; Federico Falchi; Martina Timmoneri; Beatrice Mercorelli; Arianna Loregian; Giorgio Palù; Gualtiero Alvisi
Journal:  Viruses       Date:  2021-05-20       Impact factor: 5.048

9.  Cytomegalovirus Infection and the Implications of Drug-Resistant Mutations in Pediatric Allogeneic Hematopoietic Stem Cell Transplant Recipients: A Retrospective Study from a Tertiary Hospital in China.

Authors:  Uet Yu; Xiaodong Wang; Xiaoling Zhang; Chunjing Wang; Chunlan Yang; Xiaohui Zhou; Yue Li; Xiaochan Huang; Jing Wen; Feiqiu Wen; Sixi Liu
Journal:  Infect Dis Ther       Date:  2021-05-08
  9 in total

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