Marta Varela1,2, Esben T Petersen3, Xavier Golay4, Joseph V Hajnal1,2. 1. Department of Biomedical Engineering, Division of Imaging Sciences, King's College London, London, UK. 2. Imaging Sciences Department, MRC Clinical Sciences Centre, Imperial College London, London, UK. 3. Department of Radiology, University Medical Center, Utrecht, The Netherlands. 4. UCL Institute of Neurology, University College London, London, UK.
Abstract
PURPOSE: To measure cerebral blood flow (CBF) using Look-Locker arterial spin labeling (ASL) in children under 1 year of age and to investigate the advantages of using subject-specific estimates of ASL model parameters in this population. MATERIALS AND METHODS: Of 12 scanned infants, we successfully acquired CBF maps in 7 (postmenstrual age: 32 to 78 weeks) using a Look-Locker ASL scheme and both adult literature-derived and subject-specific model parameters. ASL global CBF measurements were compared with independent global CBF measurements obtained in the same scanning session using phase-contrast angiography. RESULTS: Measured global CBF values ranged from 24 to 56 mL/100g/min in the scanned infants, increasing significantly with postmenstrual age (ρSpearman = 0.89, P-value = 0.01). Using subject-specific model parameters yielded CBF estimates in significantly better agreement with phase-contrast angiography values (P-value: 0.80) than when standard adult parameters were used (P-value: 0.04). CONCLUSION: Look-Locker ASL can be used to measure CBF in infants and its accuracy is improved with the use of infant-specific auxiliary parameters, particularly blood and tissue T1 , which were much more variable in the imaged infants in than adults.
PURPOSE: To measure cerebral blood flow (CBF) using Look-Locker arterial spin labeling (ASL) in children under 1 year of age and to investigate the advantages of using subject-specific estimates of ASL model parameters in this population. MATERIALS AND METHODS: Of 12 scanned infants, we successfully acquired CBF maps in 7 (postmenstrual age: 32 to 78 weeks) using a Look-Locker ASL scheme and both adult literature-derived and subject-specific model parameters. ASL global CBF measurements were compared with independent global CBF measurements obtained in the same scanning session using phase-contrast angiography. RESULTS: Measured global CBF values ranged from 24 to 56 mL/100g/min in the scanned infants, increasing significantly with postmenstrual age (ρSpearman = 0.89, P-value = 0.01). Using subject-specific model parameters yielded CBF estimates in significantly better agreement with phase-contrast angiography values (P-value: 0.80) than when standard adult parameters were used (P-value: 0.04). CONCLUSION: Look-Locker ASL can be used to measure CBF in infants and its accuracy is improved with the use of infant-specific auxiliary parameters, particularly blood and tissue T1 , which were much more variable in the imaged infants in than adults.
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