Literature DB >> 25142941

Five new anthraquinones from the seed of Cassia obtusifolia.

Yi-Long Xu1, Li-Ying Tang, Xi-Dan Zhou, Guo-Hong Zhou, Zhu-Ju Wang.   

Abstract

A phytochemical investigation on the seeds of Cassia obtusifolia led to the isolation of five new anthraquinones, including one aglycon and four glycosides. The structures were elucidated by analysis of extensive spectroscopic data and the results of acid hydrolysis. All these isolates were evaluated for their inhibitory effects against α-glucosidase, and 1 showed potent activity with IC50 value of 185 ± 15 µM.

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Year:  2014        PMID： 25142941     DOI： 10.1007/s12272-014-0462-x

Source DB:  PubMed          Journal:  Arch Pharm Res        ISSN： 0253-6269            Impact factor:   4.946


  4 in total

1.  Simultaneous Determination of Seven Anthraquinone Aglycones of Crude and Processed Semen Cassiae Extracts in Rat Plasma by UPLC-MS/MS and Its Application to a Comparative Pharmacokinetic Study.

Authors:  Rixin Guo; Hongwei Wu; Xiankuo Yu; Mengying Xu; Xiao Zhang; Liying Tang; Zhuju Wang
Journal:  Molecules       Date:  2017-10-28       Impact factor: 4.411

2.  Promising Inhibitory Effects of Anthraquinones, Naphthopyrone, and Naphthalene Glycosides, from Cassia obtusifolia on α-Glucosidase and Human Protein Tyrosine Phosphatases 1B.

Authors:  Hyun Ah Jung; Md Yousof Ali; Jae Sue Choi
Journal:  Molecules       Date:  2016-12-27       Impact factor: 4.411

Review 3.  A Review on Potential Mechanisms of Terminalia chebula in Alzheimer's Disease.

Authors:  Amir R Afshari; Hamid R Sadeghnia; Hamid Mollazadeh
Journal:  Adv Pharmacol Sci       Date:  2016-01-28

4.  Metabolite identification of gut microflora-cassia seed interactions using UPLC-QTOF/MS.

Authors:  Su-Hui Wu; Han-Bing Li; Gen-Lin Li; Ning Lv; Yue-Juan Qi
Journal:  Exp Ther Med       Date:  2020-03-09       Impact factor: 2.447
  4 in total

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