PURPOSE: The aim of this study was to evaluate the impact of memory complaints on quality of life (QOL) in elderly community dwellers with or without mild cognitive impairment (MCI). METHODS: Participants included 120 normal controls (NC) and 37 with MCI aged 65 and over. QOL was measured using the Japanese version of Satisfaction in Daily Life, and memory complaints were measured using a questionnaire consisting of four items. The relevance of QOL was evaluated with psychological factors of personality traits, sense of self-efficacy, depressive mood, self-evaluation of daily functioning, range of social activities (Life-Space Assessment), social network size, and cognitive functions including memory. The predictors of QOL were analyzed by multiple linear regression analysis. RESULTS: QOL was not significantly different between the NC and MCI groups. In both groups, QOL was positively correlated with self-efficacy, daily functioning, social network size, Life-Space Assessment, and the personality traits of extraversion and agreeableness; QOL was negatively correlated with memory complaints, depressive mood, and the personality trait of neuroticism. In regression analysis, memory complaints were a negative predictor of QOL in the MCI group, but not in the NC group. The partial correlation coefficient between QOL and memory complaints was -0.623 (P < 0.05), after scores of depressive mood and self-efficacy were controlled. Depressive mood was a common negative predictor in both groups. Positive predictors were Life-Space Assessment in the NC group and sense of self-efficacy in the MCI group. CONCLUSIONS: Memory complaints exerted a negative impact on self-rated QOL in the MCI group, whereas a negative correlation was weak in the NC group. Memory training has been widely practised in individuals with MCI to prevent the development of dementia. However, such approaches inevitably identify their memory deficits and could aggravate their awareness of memory decline. Thus, it is critical to give sufficient consideration not to reduce QOL in the intervention for those with MCI.
PURPOSE: The aim of this study was to evaluate the impact of memory complaints on quality of life (QOL) in elderly community dwellers with or without mild cognitive impairment (MCI). METHODS:Participants included 120 normal controls (NC) and 37 with MCI aged 65 and over. QOL was measured using the Japanese version of Satisfaction in Daily Life, and memory complaints were measured using a questionnaire consisting of four items. The relevance of QOL was evaluated with psychological factors of personality traits, sense of self-efficacy, depressive mood, self-evaluation of daily functioning, range of social activities (Life-Space Assessment), social network size, and cognitive functions including memory. The predictors of QOL were analyzed by multiple linear regression analysis. RESULTS: QOL was not significantly different between the NC and MCI groups. In both groups, QOL was positively correlated with self-efficacy, daily functioning, social network size, Life-Space Assessment, and the personality traits of extraversion and agreeableness; QOL was negatively correlated with memory complaints, depressive mood, and the personality trait of neuroticism. In regression analysis, memory complaints were a negative predictor of QOL in the MCI group, but not in the NC group. The partial correlation coefficient between QOL and memory complaints was -0.623 (P < 0.05), after scores of depressive mood and self-efficacy were controlled. Depressive mood was a common negative predictor in both groups. Positive predictors were Life-Space Assessment in the NC group and sense of self-efficacy in the MCI group. CONCLUSIONS: Memory complaints exerted a negative impact on self-rated QOL in the MCI group, whereas a negative correlation was weak in the NC group. Memory training has been widely practised in individuals with MCI to prevent the development of dementia. However, such approaches inevitably identify their memory deficits and could aggravate their awareness of memory decline. Thus, it is critical to give sufficient consideration not to reduce QOL in the intervention for those with MCI.
Authors: Laura E Middleton; Maria I Ventura; Wendy Santos-Modesitt; Gina Poelke; Kristine Yaffe; Deborah E Barnes Journal: Contemp Clin Trials Date: 2017-10-21 Impact factor: 2.226
Authors: Melanie T Gentry; Maria I Lapid; Jeremy Syrjanen; Kendrick Calvert; Samantha Hughes; Danielle Brushaber; Walter Kremers; Jessica Bove; Patrick Brannelly; Giovanni Coppola; Christina Dheel; Bradley Dickerson; Susan Dickinson; Kelley Faber; Julie Fields; Jamie Fong; Tatiana Foroud; Leah Forsberg; Ralitza Gavrilova; Deb Gearhart; Nupur Ghoshal; Jill Goldman; Jonathan Graff-Radford; Neill Graff-Radford; Murray Grossman; Dana Haley; Hilary Heuer; Ging-Yuek Hsiung; Edward Huey; David Irwin; David Jones; Lynne Jones; Kejal Kantarci; Anna Karydas; David Knopman; John Kornak; Joel Kramer; Walter Kukull; Diane Lucente; Codrin Lungu; Ian Mackenzie; Masood Manoochehri; Scott McGinnis; Bruce Miller; Rodney Pearlman; Len Petrucelli; Madeline Potter; Rosa Rademakers; Eliana Marisa Ramos; Katherine Rankin; Katya Rascovsky; Pheth Sengdy; Leslie Shaw; Nadine Tatton; Joanne Taylor; Arthur Toga; John Trojanowski; Sandra Weintraub; Bonnie Wong; Zbigniew Wszolek; Bradley F Boeve; Adam Boxer; Howard Rosen Journal: Alzheimers Dement Date: 2020-07-13 Impact factor: 21.566
Authors: Leonie C P Banning; Eveline P C J Janssen; Renske E G Hamel; Marjolein de Vugt; Sebastian Köhler; Claire A G Wolfs; Saskia M Oosterveld; Rene J F Melis; Marcel G M Olde Rikkert; Roy P C Kessels; Yolande A L Pijnenburg; Ted Koene; Wiesje M van der Flier; Philip Scheltens; Pieter Jelle Visser; Frans R J Verhey; Pauline Aalten; Inez H G B Ramakers Journal: J Geriatr Psychiatry Neurol Date: 2019-10-23 Impact factor: 2.680
Authors: Rosalinde E R Slot; Sander C J Verfaillie; Jozefien M Overbeek; Tessa Timmers; Linda M P Wesselman; Charlotte E Teunissen; Annemiek Dols; Femke H Bouwman; Niels D Prins; Frederik Barkhof; Adriaan A Lammertsma; Bart N M Van Berckel; Philip Scheltens; Sietske A M Sikkes; Wiesje M Van der Flier Journal: Alzheimers Res Ther Date: 2018-08-07 Impact factor: 6.982